{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:38:00Z","timestamp":1703183880224},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Birth Defects Registry of the Massachusetts Department of Public Health"},{"name":"Birth Defects and Developmental Disabilities Center of the Centers for Disease Control, Atlanta"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The number of affected infants and the types of malformations identified by a malformation surveillance programs can be impacted if elective terminations for malformations are not included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The occurrence of malformations in all newborn infants was determined in a daily review of the findings in the pediatricians' examinations and those of all consultants. In addition, the findings in autopsies of all elective terminations were reviewed to identify all fetuses with structural abnormalities. A severity scale was used to subdivide the malformations. To establish the impact of elective termination, the malformed infants identified in the Active Malformations Surveillance Program at Brigham and Women's Hospital in Boston were analyzed for the 2 years before and after the hospital decreased significantly the number of elective terminations temporarily (1999\u20132000 vs. 2001\u20132002). The effect on the number of malformations identified at birth, as well as malformations of greater severity, was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of terminated fetuses with malformations decreased dramatically after termination services were interrupted (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). There were no differences in the prevalence rates of all malformations in the 2 years before and after the change in access to elective terminations. However, there were significant decreases in the number of infants identified with lethal\/life\u2010limiting and severe\/handicapping malformations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the surveillance for malformations among newborn infants, the inclusion of malformed fetuses from elective terminations had a significant effect on the number of infants with the more severe malformations identified. Birth Defects Research (Part A) 106:659\u2013666, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23510","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T09:17:59Z","timestamp":1461748679000},"page":"659-666","source":"Crossref","is-referenced-by-count":9,"title":["Impact of elective termination on the occurrence of severe birth defects identified in a hospital\u2010based active malformations surveillance program (1999 to 2002)"],"prefix":"10.1002","volume":"106","author":[{"given":"Emma G.","family":"Thomas","sequence":"first","affiliation":[{"name":"Active Malformations Surveillance Program, Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"},{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Hassan","family":"Toufaily","sequence":"additional","affiliation":[{"name":"Active Malformations Surveillance Program, Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"},{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Noel","family":"Westgate","sequence":"additional","affiliation":[{"name":"Active Malformations Surveillance Program, Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"},{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Therese","family":"Hunt","sequence":"additional","affiliation":[{"name":"Hunt Consulting Associates, Thetford Center  Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela E.","family":"Lin","sequence":"additional","affiliation":[{"name":"Active Malformations Surveillance Program, Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"},{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis B.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Active Malformations Surveillance Program, Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts"},{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis \u2013 United States, 1984\u20101994","volume":"44","author":"Cragan JD","year":"1995","journal-title":"MMWR CDC Surveill Summ"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66391-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.90008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.022"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009610"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33999"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20842"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23001"},{"key":"e_1_2_6_10_1","volume-title":"Common Malformations","author":"Holmes LB.","year":"2012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70152-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142718.53380.8f"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30904"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960102)61:1<49::AID-AJMG10>3.0.CO;2-W"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10012"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:58:04Z","timestamp":1695715084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,26]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/bdra.23510"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23510","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,26]]}}}