{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:47:51Z","timestamp":1782953271637,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373014"],"award-info":[{"award-number":["81373014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["41401583"],"award-info":[{"award-number":["41401583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Shanxi Province is a region in China with a high incidence of orofacial clefts (OFCs). Our objective is to investigate the effect of maternal exposure to indoor air pollution (IAP) from coal combustion and tobacco smoke on the risk of an infant being born with orofacial clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were derived from an ongoing population\u2010based case\u2013control study of major external structural birth defects in Shanxi Province. Subjects included 213 cases with OFCs and 1319 healthy babies born between November 2002 and December 2014 in four rural counties. Exposure information was collected by face\u2010to\u2010face interview with mothers within 1 week of delivery or pregnancy termination. The authors derived an exposure index by integrating a series of IAP\u2010related characteristics concerning dwelling and lifestyle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased odds of OFC were associated with IAP exposure from heating (adjusted odds ratio [aOR] = 2.4; 95% confidence interval [CI], 1.2\u20134.5) and from smoking (aOR = 1.8; 95% CI: 1.3, 2.5), but not with exposure from cooking (aOR = 0.9; 95% CI, 0.6\u20131.4). Compared with women without IAP exposure, the aORs of OFC for children of women with exposure indices of 1, 2, 3 and \u2265 4 were 1.1 (95% CI, 0.6\u20131.8), 1.4 (95% CI, 0.8\u20132.4), 1.8 (95% CI, 1.0\u20133.2), and 3.4 (95% CI, 1.6\u20137.4), respectively, demonstrating a clear dose\u2013response trend (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Periconceptional exposure to IAP from coal combustion and tobacco smoking may increase the risk of OFCs in offsprings of women in Shanxi Province. Birth Defects Research (Part A) 106:708\u2013715, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23522","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T16:43:01Z","timestamp":1464280981000},"page":"708-715","source":"Crossref","is-referenced-by-count":16,"title":["Indoor air pollution and the risk of orofacial clefts in a rural population in Shanxi province, China"],"prefix":"10.1002","volume":"106","author":[{"given":"Yingying","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health, Peking University  China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health, Peking University  China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health, Peking University  China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health, Peking University  China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health, Peking University  China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health, Peking University  China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1972.tb11887.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(88)90041-0"},{"key":"e_1_2_6_4_1","first-page":"94","article-title":"Embryo toxicity of benzo(a)pyrene and some of its synthetic derivatives in Swiss mice","volume":"46","author":"Barbieri O","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2005.08.003"},{"key":"e_1_2_6_6_1","first-page":"1078","article-title":"Indoor air pollution in developing countries: a major environmental and public health challenge","volume":"78","author":"Bruce N","year":"2000","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080105"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200002000-00001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.045997"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240405"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod19.1.8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/es049942k"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi189"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059161"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005408"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11311"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/es0507517"},{"key":"e_1_2_6_18_1","first-page":"333","article-title":"Does maternal cigarette smoking during pregnancy cause cleft lip and palate in offspring?","volume":"143","author":"Khoury MJ","year":"1989","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.77.5.623"},{"key":"e_1_2_6_20_1","first-page":"728","article-title":"Investigation on indoor air pollution from coal burning in rural area of Shanxi Province [in Chinese]","volume":"22","author":"Li Z","year":"2006","journal-title":"Chin J Public Health"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32492"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00694.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr108"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-142.1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.90.3.415"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2008.03.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390701601376"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2008.11.007"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.1.17"},{"key":"e_1_2_6_30_1","first-page":"551","article-title":"Orofacial clefts, parental cigarette smoking, and transforming growth factor\u2010alpha gene variants","volume":"58","author":"Shaw GM","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp011"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.1990.tb00630.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000129"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23522","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:58:19Z","timestamp":1695715099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/bdra.23522"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23522","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}