{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:41:14Z","timestamp":1785195674755,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Coordination for the Improvement of Higher Education (CAPES), Brazil","award":["2462-15-0"],"award-info":[{"award-number":["2462-15-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The birth prevalence of cleft lip with or without cleft palate (CL\/P) in Brazil increased between the years from 1975 to 1994 but has not been evaluated for temporal trend since then.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the Brazilian National Health Information System for the years 2000 through 2013. We calculated the reported CL\/P birth prevalence each year per 10,000 live births and estimated the average increase in reported prevalence per year (and 95% confidence interval [CI]) by fitting a negative binomial regression model. We also estimated the temporal trend in each of the five Brazilian regions for this time period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall reported birth prevalence was 4.85 (95% CI, 4.78\u20134.91) per 10,000 live births. The reported birth prevalence of CL\/P increased over this time period, from 3.94 (95% CI, 3.73\u20134.17) per 10,000 in 2000 to 5.46 (95% CI, 5.20\u20135.74) per 10,000 in 2013. The temporal trend differed for different Brazilian geographic regions, being confined primarily to the Northeast (4.7% per year; 95% CI, 4.0%\u20135.5%), North (3.3% per year; 95% CI, 1.8%\u20134.7%), and Central (2.9% per year; 95% CI, 0.9%\u20134.9%) regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In recent years, there appears to be an upward trend in the reported prevalence of CL\/P in Brazil, confined to the less developed regions of the country. The increase likely reflects improved surveillance; whether it also reflects etiologic differences is unknown. Birth Defects Research (Part A) 106:789\u2013792, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23528","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T10:59:00Z","timestamp":1464951540000},"page":"789-792","source":"Crossref","is-referenced-by-count":26,"title":["Temporal trend in the reported birth prevalence of cleft lip and\/or cleft palate in Brazil, 2000 to 2013"],"prefix":"10.1002","volume":"106","author":[{"given":"Mauro Henrique Nogueira Guimar\u00e3es","family":"Abreu","sequence":"first","affiliation":[{"name":"Department of Community and Preventive Dentistry UFMG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Ha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Oral Sciences The Forsyth Institute Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Varela","family":"Luquetti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Rose","family":"Starr","sequence":"additional","affiliation":[{"name":"Department of Applied Oral Sciences The Forsyth Institute Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20315"},{"key":"e_1_2_6_3_1","first-page":"246","article-title":"[Factors associated with folic acid use during pregnancy]","volume":"33","author":"Barbosa L","year":"2011","journal-title":"Rev Bras Ginecol Obstet"},{"key":"e_1_2_6_4_1","volume-title":"Manual de instru\u00e7\u00f5es para preenchimento da declara\u00e7\u00e3o de nascido vivo","author":"Funda\u00e7\u00e3o Nacional de Sa\u00fade","year":"2001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058690"},{"key":"e_1_2_6_6_1","first-page":"2095","article-title":"[Review of data quality dimensions and applied methods in the evaluation of health information systems]","volume":"25","author":"Lima CR","year":"2009","journal-title":"Cad Saude Publica"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102001000600011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2008000500022"},{"key":"e_1_2_6_9_1","first-page":"112","article-title":"Validity and reliability of the Brazilian birth certificate for reporting birth defects","volume":"37","author":"Luquetti DV","year":"2010","journal-title":"J Registry Manag"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1991)028<0373:EOOCIA>2.3.CO;2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2007001100019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.5123\/S1679-49742015000400005"},{"issue":"7","key":"e_1_2_6_13_1","first-page":"S11","article-title":"Global birth prevalence of orofacial clefts: a systematic review","volume":"98","author":"Panamonta V","year":"2015","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32076"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20207"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2013.03.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60055-X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-035"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23528","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T04:18:46Z","timestamp":1696652326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/bdra.23528"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23528","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}