{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:46:33Z","timestamp":1775220393768,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T00:00:00Z","timestamp":1465862400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Supported by The German Federal Office for Radiation Protection (Bundesamt f\u00fcr Strahlenschutz)","award":["3610S40004"],"award-info":[{"award-number":["3610S40004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The evidence concerning safety of occupational exposure to ionizing radiation on teratogenic effects mainly relies on animal models, disaster epidemiology and experience in cancer etiology. Following an explorative result on maternal exposure in medical occupations we conducted a feasibility study, addressing congenital anomalies (CA) in the offspring of health workers potentially exposed to radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective follow\u2010up study, we enrolled women, identified by mandatory registration at the office of radiation protection as wearing a dosimeter. The participating women answered a questionnaire and if pregnant agreed to an examination of their infant. CA were diagnosed and categorized, and demographic and anamnestic findings (including dosimeter values) were ascertained. Mainz Birth Registry data were used for comparison, and a nonresponder analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Answers were received from 286 of 604 (51%) women exposed and 183 (30.3%) of them participated in the study including 88 nonparticipants who provided exposure data only. Further sources of ionizing radiation and other factors relevant for CA did not differ between the groups. Thirty pregnancies occurred among the participants. Eight of the resulting 27 infants were diagnosed with CA (30%) compared with 6.2% of the comparison group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous explorative findings were corroborated by this feasibility study. The increased prevalence for CA could not be explained by any other factor. A preferable prospective active design is achievable, and the participation rate is essential to calculate valid results and answer this important issue. Birth Defects Research (Part A) 106:475\u2013479, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23532","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T14:03:39Z","timestamp":1465999419000},"page":"475-479","source":"Crossref","is-referenced-by-count":4,"title":["Evidence for a teratogenic risk in the offspring of health personnel exposed to ionizing radiation?!"],"prefix":"10.1002","volume":"106","author":[{"given":"Awi","family":"Wiesel","sequence":"first","affiliation":[{"name":"Birth Registry Mainz Model, Children's Hospital, University Medical Center of Mainz Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Stolz","sequence":"additional","affiliation":[{"name":"Birth Registry Mainz Model, Children's Hospital, University Medical Center of Mainz Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Queisser\u2010Wahrendorf","sequence":"additional","affiliation":[{"name":"Birth Registry Mainz Model, Children's Hospital, University Medical Center of Mainz Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"187","article-title":"Infantile umbilical hernia","volume":"150","author":"Blumberg NA","year":"1980","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20099"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02812-9"},{"key":"e_1_2_7_5_1","unstructured":"EUROCAT Special Report: Congenital anomalies are a major group of mainly rare diseases.2012.Eurocat central registry University of Ulster Northern Ireland. 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