{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:29:54Z","timestamp":1776371394115,"version":"3.51.2"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis of interferon regulatory factor 6 and 8q24 polymorphisms with nonsyndromic cleft lip with\/without cleft palate (NSCL\/P).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data extraction was independently performed by two reviewers. Genotypic effects of four polymorphisms from 31 studies were pooled separately by ethnicity using a mixed\u2010effect logit model with accounting for heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For rs2235371, AA and GA carried, respectively, 51% (95% confidence interval [CI], 37%\u201361%) and 42% (95% CI, 32%\u201350%) lower risks of NSCL\/P than GG genotypes in Asians, but these genotypes were not significant in Caucasians. For rs2013162, only AA was significant, that is, carried 0.65 (95% CI, 0.52\u20130.82) times lower odds than CC in Caucasians but not for Asians. For rs642961, AA and GA genotypes, respectively, carried 2.47 (95% CI, 1.41\u20134.35) and 1.40 (95% CI, 1.12\u20131.75) times higher odds in Asian, and 2.03 (95% CI, 1.52\u20132.71) and 1.58 (95% CI, 1.37\u20131.82) times higher odds in Caucasians compare with GG genotypes. For rs987525, AA and CA genotypes carried 2.27 (95% CI, 1.43\u20133.60) and 1.34 (95% CI, 1.02\u20131.77) times higher odds in Asian, and 5.25 (95% CI, 3.98\u20136.91) and 2.13 (95% CI\u20131.82, 2.49) times higher odds in Caucasians, and 1.42 (95% CI, 1.10\u20131.82) and 1.28 (95% CI, 1.09\u20131.50) times higher odds in mixed ethnicities compared with CC genotypes. These variant effects remained significant based on applying Bonferroni corrected\u2010thresholds, except in the mixed ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We show robust variant effects in NSCL\/P. Considering them with other genes and risk factors might be useful to improve prediction of NSCL\/P occurrence. 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