{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:26Z","timestamp":1786977146092,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T00:00:00Z","timestamp":1470355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jiangsu Provincial Special Program of Medical Science in China","award":["BL2013003"],"award-info":[{"award-number":["BL2013003"]}]},{"name":"Jiangsu Provincial Graduate Student Research Innovation Project in China","award":["KYLX_0932"],"award-info":[{"award-number":["KYLX_0932"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Esophageal atresia (EA) is a common birth defect that occurs with tracheoesophageal fistula (TEF), although etiological studies on EA\/TEF have produced inconsistent results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The aim of this study was to examine the association between environmental factors during pregnancy and the risk of EA\/TEF in a Chinese population. Cases of isolated EA and nonisolated EA and unaffected controls were identified between July 2005 and November 2015, and face\u2010to\u2010face questionnaires concerning exposure to environmental factors were administered to the birth mothers of 130 cases and 400 controls. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association between environmental factors and the risk of EA\/TEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results of this case\u2013control study suggest that lower maternal education (p\u2009&lt;\u20090.0001), maternal binge drinking (OR\u2009=\u20092.63; 95% CI, 1.05\u20136.6) and pickled food consumption (OR\u2009=\u20092.04; 95% CI, 1.31\u20133.71) during pregnancy increase the risk of EA in offspring, while maternal folic acid supplementation (OR\u2009=\u20090.45; 95% CI, 0.29\u20130.71) is significantly associated with a decreased risk of EA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest a role for environmental exposures in the etiology of EA\/TEF; however, further studies are needed to replicate the observed associations. Birth Defects Research (Part A) 106:840\u2013846, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdra.23550","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T11:48:51Z","timestamp":1470397731000},"page":"840-846","source":"Crossref","is-referenced-by-count":10,"title":["Environmental factors in the etiology of isolated and nonisolated esophageal atresia in a Chinese population: A case\u2013control study"],"prefix":"10.1002","volume":"106","author":[{"given":"Yu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery The Affiliated Nanjing Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runsen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The Affiliated Nanjing Children's Hospital of Nanjing Medical University 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