{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:49:37Z","timestamp":1761562177459},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Delaware Department of Public Health and Social Services","award":["14-180"],"award-info":[{"award-number":["14-180"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of ventricular septal defects (VSDs), a birth defect in which there is an opening in the wall that separates the left and right ventricles of the heart, seemed to be substantially higher in Delaware compared with the National Birth Defects Prevention Network (NBDPN). The Delaware Birth Defects Registry (BDR) noted their high prevalence of VSDs in comparison with other states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A subset of children with a VSD born in 2007 through 2010 was identified from the complete reportable statewide defect list that the BDR creates each year. VSDs were categorized by type of VSD (muscular, perimembranous, conotruncal, or atrioventricular septal defect), by either isolated or complex, and then by spontaneously closed, surgically closed, open but clinically insignificant, lost to follow\u2010up, fetal or neonatal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BDR team found a prevalence of VSD of 83.4 per 10,000 including fetal\/neonatal deaths. Excluding fetal and neonatal deaths the prevalence was 78.7 per 10,000 live births. Excluding small muscular VSDs, the prevalence in Delaware falls to 25.7 per 10,000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The BDR team chose to include all babies with all types of VSDs. Using these criteria Delaware's prevalence of 78.7 was higher than that reported by other states (whose prevalence ranges from 1.6 to 70.0 per 10,000 live births) (National Birth Defects Prevention Network, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bdra23574-bib-0014\" \/>). Delaware's prevalence is similar to other states when small muscular VSDs are excluded. Birth Defects Research (Part A) 106:888\u2013893, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23574","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T05:15:28Z","timestamp":1480310128000},"page":"888-893","source":"Crossref","is-referenced-by-count":4,"title":["Surveillance of ventricular septal defects in Delaware"],"prefix":"10.1002","volume":"106","author":[{"given":"Amy","family":"Acheson","sequence":"first","affiliation":[{"name":"Center for Women's, Infants' and Children's Health Research Christiana Care Health System Newark Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Vaidy","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Stomieroski","sequence":"additional","affiliation":[{"name":"Center for Women's, Infants' and Children's Health Research Christiana Care Health System Newark Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Center for Women's, Infants' and Children's Health Research Christiana Care Health System Newark Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin M.","family":"Maiden","sequence":"additional","affiliation":[{"name":"Division of Health and Prevention Services Nemours Children's Health System Wilmington Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah B.","family":"Ehrenthal","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynecology and Population Health Sciences, School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Yezdani","sequence":"additional","affiliation":[{"name":"The Lewis Katz School of Medicine at Temple University Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Majeed","family":"Bhat","sequence":"additional","affiliation":[{"name":"Nemours Alfred I. duPont Hospital for Children Wilmington Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Locke","sequence":"additional","affiliation":[{"name":"Neonatology, Christiana Care Health System, Newark Delaware and Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis E.","family":"Bartoshesky","sequence":"additional","affiliation":[{"name":"Pediatrics, Christiana Care Health System, Newark Delaware and Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2716"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23111"},{"key":"e_1_2_6_5_1","unstructured":"Center for Disease Control and Prevention (CDC).Congenital Heart Defects (CHDs) \u2013 facts about ventricular septal defect. Available at:http:\/\/www.cdc.gov\/ncbddd\/heartdefects\/VentricularSeptalDefect.html. Accessed June 10 2016."},{"key":"e_1_2_6_6_1","first-page":"315","article-title":"Evolution of ventricular septal defect with special reference to spontaneous closure rate, subaortic ridge and aortic valve prolapse","volume":"24","author":"Eroglu AG","year":"2003","journal-title":"Pediatr Cardiol"},{"key":"e_1_2_6_7_1","first-page":"271","article-title":"Atrial and ventricular septal defects","volume":"19","author":"Game E","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12527"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008396"},{"key":"e_1_2_6_10_1","volume-title":"Heart disease in infants, children and adolescents","author":"McDaniel NL","year":"2010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90620-E"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/080352500300002552"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618124"},{"key":"e_1_2_6_14_1","first-page":"S1","article-title":"Major birth defects from population\u2010based birth defects surveillance programs in the United States 2006 \u2013 2010","volume":"97","author":"National Birth Defects Prevention Network","year":"2013","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"e_1_2_6_15_1","first-page":"S1","article-title":"Major birth defects data from population based birth defects surveillance programs in United States 2008\u20102012","volume":"103","author":"National Birth Defects Prevention Network","year":"2015","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"e_1_2_6_16_1","unstructured":"National Birth Defects Prevention Network.2015b.Guidelines for conducting birth defects surveillance. 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