{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:53:37Z","timestamp":1763747617346,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR025764","NIH\/NCI 1KM1CA156723"],"award-info":[{"award-number":["UL1RR025764","NIH\/NCI 1KM1CA156723"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of prenatal diagnosis of d\u2010transposition of the great arteries (dTGA) on health\u2010care usage is largely unknown. We evaluated a population\u2010based cohort to assess costs, mortality and inpatient encounters by whether dTGA was prenatally diagnosed or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The dTGA cases (born 1997\u20132011) identified at the Utah Birth Defect Network, which includes data on timing of diagnosis, were linked to statewide inpatient discharge data. We excluded preterm cases or cases with additional major heart defects. We evaluated hospitalizations and costs for infants (first year of life) and mothers (10 months before birth) using multivariable models adjusted for demographic and clinical risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 119 cases, 14 (12%) were prenatally diagnosed. Birth weight, surgical complexity and extracardiac defects\/syndromes were similar between groups. Of 7 deaths (6%), two occurred pre\u2010intervention in postnatally diagnosed infants. Prenatal diagnosis was associated with more in\u2010hospital days (estimate 13 additional days, p\u2009=\u20090.03) and higher mean costs for mothers ($4,141 vs $12,148) and infants (90,419 vs $49,576). Prenatal diagnosis independently predicted higher adjusted costs for the overall cohort ($22,570, p\u2009=\u20090.045). After excluding deaths, total costs were no longer significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mothers of prenatally diagnosed infants with dTGA had higher inpatient costs compared with those postnatally diagnosed. Costs trended higher for their infants, although were not significantly different. Linkage of population\u2010based surveillance systems and outcome databases can be a powerful tool to further explore the complex relationship of prenatal diagnosis to costs and outcomes in other types of congenital heart diseases. Birth Defects Research 109:262\u2013270, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23608","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T10:52:49Z","timestamp":1486983169000},"page":"262-270","source":"Crossref","is-referenced-by-count":6,"title":["Costs, mortality, and hospital usage in relation to prenatal diagnosis in d\u2010transposition of the great arteries"],"prefix":"10.1002","volume":"109","author":[{"given":"Nelangi M.","family":"Pinto","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics, University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Department of Internal Medicine, University of Utah Salt Lake City 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