{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:00:04Z","timestamp":1785416404727,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Science and Technology Research of Chongqing Municipal Health Bureau","award":["No.2011-2-190"],"award-info":[{"award-number":["No.2011-2-190"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2017,4,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the association between the noggin rs227731 polymorphism on chromosome 17q22 and risk of nonsyndromic cleft lip with or without palate (NSCL\/P).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three online databases were searched, including Embase, PubMed, and Chinese National Knowledge Infrastructure. The strength of the associations was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). We also made a subgroup analysis to explore sources of heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine comparisons from seven studies were included in this meta\u2010analysis. We used five genetic models and found that the noggin rs227731 polymorphism may increase NSCL\/P risk in Caucasians: C versus A: OR = 1.43, 95% CI, 1.30\u20131.58; CC versus AA: OR = 2.00, 95% CI, 1.59\u20132.52; CA versus AA: OR = 1.50, 95% CI, 1.27\u20131.77; CC+CA versus AA: OR = 1.64, 95% CI, 1.40\u20131.92; CC versus CA+AA: OR = 1.56, 95% CI, 1.30\u20131.87. However, for the Chinese population, no significant association between the rs227731 polymorphism and NSCL\/P risk was found: C vs. A: OR = 1.04, 95% CI, 0.81\u20131.33; CC vs. AA: OR = 1.01, 95% CI, 0.52\u20131.95; CA vs. AA: OR = 1.03, 95% CI, 0.75\u20131.40; CC+CA vs. AA: OR = 1.04, 95% CI, 0.76\u20131.43; CC vs. CA+AA: OR = 1.01, 95% CI, 0.56\u20131.81.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis suggested that the rs227731 polymorphism may increase NSCL\/P risk in Caucasians and may have no significant association in the Chinese population. Effects of individual and environmental risk factors and of gene\u2013environment interactions may play a different role in Caucasians than in the Chinese population. More relevant case\u2013control studies are required to obtain more precise results. Birth Defects Research 109:445\u2013451, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23612","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:53:11Z","timestamp":1487695991000},"page":"445-451","source":"Crossref","is-referenced-by-count":4,"title":["Associations between the <i>NOGGIN<\/i> rs227731 polymorphism and NSCL\/P risk may be associated with ethnicities: A meta\u2010analysis"],"prefix":"10.1002","volume":"109","author":[{"given":"Feilong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, the Affiliated Stomatology Hospital Chongqing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, the Affiliated Stomatology Hospital Chongqing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, the Affiliated Stomatology Hospital Chongqing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Management Chongqing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, the Affiliated Stomatology Hospital Chongqing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, the Affiliated Stomatology Hospital Chongqing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23204"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32227-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.08.014"},{"key":"e_1_2_5_6_1","unstructured":"HigginsJ.2013.Green S. 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