{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:02:31Z","timestamp":1784120551562,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,8,26]],"date-time":"2003-08-26T00:00:00Z","timestamp":1061856000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> Gastroschisis is a rare congenital defect of the abdominal wall. Its occurrence is noted primarily in the offspring of young mothers who often smoke during pregnancy. The incidence of gastroschisis has been increasing in many countries in recent years. The etiology of gastroschisis is not known. <jats:bold>METHODS:<\/jats:bold> Pregnant mice of CD\u20101 strain were maintained on 17 and 9% protein diets mixed with deficient, normal, or supplemental zinc levels throughout gestation. The dams in each protein\u2010zinc diet group were randomly divided in two groups. One group was exposed to air (control) and the other to 500 ppm carbon monoxide (CO) in air, in environmental chambers, from gestation days (GD) 8\u201318. The dams were sacrificed by carbon dioxide asphyxiation on GD 18, and data on malformations was collected. <jats:bold>RESULTS:<\/jats:bold> The rates of fetal mortality and malformations were increased by protein and zinc deficiencies. Carbon monoxide exposure also increased fetal mortality. In the low protein group, the rate of fetal mortality was inversely related to the dietary zinc level, and the rate of fetal malformations was highest in the zinc deficient group. The incidence of gastroschisis in the low protein\/zinc deficient\/CO exposed group was 47%, and 60% of the litters were affected. The incidence of gastroschisis in the rest of the low protein\/zinc diets\/air or CO groups was 0. <jats:bold>CONCLUSION:<\/jats:bold> The data indicates that gastroschisis is caused by the combination of protein\u2010zinc deficiencies and carbon monoxide exposure during gestation. The finding may be relevant to human populations that experience protein and zinc deficiencies during gestation, and are exposed to CO pollution, or cigarette, or marijuana smoke during pregnancy. Birth Defects Res B 68:355\u2013362, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.10032","type":"journal-article","created":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T19:34:23Z","timestamp":1062531263000},"page":"355-362","source":"Crossref","is-referenced-by-count":25,"title":["Gastroschisis is caused by the combination of carbon monoxide and protein\u2010zinc deficiencies in mice"],"prefix":"10.1002","volume":"68","author":[{"given":"Jarnail","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,26]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Alabama Department of Public Health.1999.A report on the rate of smoking in Alabama."},{"key":"e_1_2_5_3_1","unstructured":"Alabama Department of Public Health.2000.A report on the rate of smoking in Alabama."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108726"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115633"},{"key":"e_1_2_5_6_1","first-page":"684","volume-title":"Principles and practice of obstetrics and perinatology","author":"Bruce NW","year":"1981"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(76)90010-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"499S","DOI":"10.1093\/ajcn\/68.2.499S","article-title":"Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival","volume":"68","author":"Caulfield L","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1970.tb49786.x"},{"key":"e_1_2_5_10_1","first-page":"439","volume-title":"Hand book of physiology: a critical, comprehensive presentation of physiological knowledge and concepts. 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