{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T11:50:12Z","timestamp":1725191412188},"reference-count":82,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T00:00:00Z","timestamp":1071705600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> \u03b2<jats:sub>2<\/jats:sub>\u2010Adrenoceptor (\u03b2AR) agonists, such as terbutaline, are widely used to arrest preterm labor. They also cross the placenta where they stimulate receptors in fetal tissues, which in turn use \u03b2AR input for trophic control of cell replication and differentiation.<\/jats:p><jats:p><jats:bold>METHODS:<\/jats:bold> As rats are altricial, we administered terbutaline in two different postnatal exposure periods (10 mg\/kg given daily on Days 2\u20135 or 11\u201314).<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Hearts were examined twenty\u2010four hours after the last dose and on postnatal day 30 for cardiac damage. Neither treatment paradigm caused an increase in cardiac abnormalities compared to controls but quantitative analysis of the number of nuclei indicated reductions in females.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> These findings do not support earlier case reports of outright myocardial necrosis after terbutaline tocolysis in human infants. Nevertheless, the significant statistical association between terbutaline and cardiac anomalies in epidemiological studies suggest that terbutaline may sensitize the developing heart to other insults that affect development. <jats:italic>Birth Defects Res B<\/jats:italic> 68:449\u2013455, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.10043","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T08:01:21Z","timestamp":1072080081000},"page":"449-455","source":"Crossref","is-referenced-by-count":2,"title":["Does terbutaline damage the developing heart?"],"prefix":"10.1002","volume":"68","author":[{"given":"Melissa C.","family":"Rhodes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Nyska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic J.","family":"Seidler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore A.","family":"Slotkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.4.R1079"},{"key":"e_1_2_6_3_1","first-page":"R1236","article-title":"\u03b2\u2010Adrenoceptor control of G\u2010protein function in the neonate: determinant of desensitization or sensitization","volume":"283","author":"Auman JT","year":"2002","journal-title":"Am J Physiol"},{"key":"e_1_2_6_4_1","first-page":"R1895","article-title":"\u03b2\u2010Adrenoceptor\u2010mediated cell signaling in the neonatal heart and liver: responses to terbutaline","volume":"281","author":"Auman JT","year":"2001","journal-title":"Am J Physiol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00122.2002"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"Beta\u2010mimetics and the preterm neonatal lung","volume":"497","author":"Bergman B","year":"1981","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_6_7_1","first-page":"81","article-title":"Transfer of terbutaline across the human placenta in late pregnancy","volume":"65","author":"Bergman B","year":"1984","journal-title":"Eur J Resp Dis"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036128"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91677-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490100210"},{"key":"e_1_2_6_11_1","first-page":"201","article-title":"Ontogenetic transition of cardiac myosin heavy chain isoforms in rat ventricle: effects of fetal exposure to \u03b2\u2010adrenergic agonists or antagonists","volume":"17","author":"Briggs MM","year":"1992","journal-title":"J Dev Physiol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198809000-00010"},{"key":"e_1_2_6_13_1","first-page":"6082","article-title":"Biochemical aspects of cardiac muscle differentiation","volume":"251","author":"Claycomb WC","year":"1976","journal-title":"J Biol Chem"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.13.1329"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1989.tb08750.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1901.097086"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.80.2.F88"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R830"},{"key":"e_1_2_6_19_1","first-page":"55","article-title":"Functional neuroteratology of drugs acting on adrenergic receptors","volume":"13","author":"Feenstra MGP","year":"1992","journal-title":"Neurotoxicology"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0002-9378(91)90377-4","article-title":"Myocardial necrosis in a newborn after long\u2010term maternal subcutaneous terbutaline infusion for suppression of preterm labor","volume":"165","author":"Fletcher SE","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00598.2001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00925-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jama.1995.03520290065031","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes","volume":"273","author":"Gilstrap LC","year":"1994","journal-title":"J Am Med Assoc"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02212-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000152200"},{"key":"e_1_2_6_26_1","first-page":"521","article-title":"Adenosine 3\u2032,5\u2032\u2010monophosphate concentrations and isoproterenol\u2010induced synthesis of deoxyribonucleic acid in mouse parotid gland","volume":"8","author":"Guidotti A","year":"1972","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70181-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00408659"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198912000-00005"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1261"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(83)90300-9"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199405000-00001"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/71.2.237"},{"key":"e_1_2_6_34_1","first-page":"129","article-title":"Selective linkage of \u03b2\u2010adrenergic receptors to functional responses in developing rat lung and liver: phosphatidic acid phosphatase, ornithine decarboxylase and lung liquid reabsorption","volume":"12","author":"Kudlacz EM","year":"1989","journal-title":"J Dev Physiol"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198906000-00013"},{"key":"e_1_2_6_36_1","first-page":"236","article-title":"Phosphatidic acid phosphatase in neonatal rat lung: effects of prenatal dexamethasone or terbutaline treatment on basal activity and on responsiveness to beta adrenergic stimulation","volume":"250","author":"Kudlacz EM","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_37_1","first-page":"307","article-title":"Regulation of neonatal rat lung compliance by \u03b2\u2010adrenergic receptor stimulation: effects of prenatal exposure to terbutaline or dexamethasone","volume":"14","author":"Kudlacz EM","year":"1990","journal-title":"J Dev Physiol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0486-100"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210553"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199811002-00001"},{"key":"e_1_2_6_41_1","first-page":"119","volume-title":"Developmental toxicology","author":"Lau C","year":"1994"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90289-5"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(78)91939-X"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119452"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000169631"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12567"},{"key":"e_1_2_6_47_1","first-page":"244","article-title":"Cardiac histological and serum\u2010biochemical changes produced by isoprenaline and terbutaline in the pigeon","volume":"5","author":"Marmo E","year":"1974","journal-title":"J Med"},{"key":"e_1_2_6_48_1","first-page":"181","article-title":"Ontogeny of rat hepatic adrenoceptors","volume":"227","author":"McMillian MK","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_49_1","first-page":"141","article-title":"Beta\u20102 adrenergic control of ornithine decarboxylase activity in brain regions of the developing rat","volume":"233","author":"Morris G","year":"1985","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243398"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(91)90157-Q"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90346-3"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026419720410"},{"key":"e_1_2_6_54_1","first-page":"H2078","article-title":"Catecholamines act via a \u03b2\u2010adrenergic receptor to maintain fetal heart rate and survival","volume":"284","author":"Portbury AL","year":"2003","journal-title":"Am J Physiol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960503)63:1<268::AID-AJMG45>3.0.CO;2-J"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199703000-00009"},{"key":"e_1_2_6_57_1","first-page":"125","article-title":"Hormonal regulation of myometrical adrenergic responses: the receptor and beyond","volume":"11","author":"Roberts JM","year":"1989","journal-title":"J Dev Physiol"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951101001123"},{"key":"e_1_2_6_59_1","first-page":"872","article-title":"Myosin isoenzyme expression in rat ventricle: effects of thyroid hormone analogs, catecholamines, glucocorticoids and high carbohydrate diet","volume":"229","author":"Sheer D","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_60_1","first-page":"H961","article-title":"\u03b2\u2010Adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy","volume":"44","author":"Shizukuda Y","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10024"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.2.F133"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.048421"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1994.1140"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1994.1247"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00282-6"},{"key":"e_1_2_6_67_1","first-page":"101","article-title":"Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development","volume":"243","author":"Slotkin TA","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(88)90040-8"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006338232150"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H2183"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199205000-00009"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198900145-00002"},{"key":"e_1_2_6_73_1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1152\/physrev.1991.71.4.991","article-title":"Fetal lung liquid: secretion and reabsorption","volume":"71","author":"Strang LB","year":"1991","journal-title":"Physiol Rev"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.1.105"},{"key":"e_1_2_6_75_1","first-page":"93","article-title":"Elimination pathways of terbutaline","volume":"65","author":"Tegner K","year":"1984","journal-title":"Eur J Resp Dis"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420520508"},{"key":"e_1_2_6_77_1","first-page":"1331","article-title":"Rapid arrest of DNA synthesis by N6,O2\u2032\u2010dibutyryl cyclic adenosine 3\u2032,5\u2032\u2010monophosphate in cultured hepatoma cells","volume":"33","author":"Van Wijk R","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_6_78_1","first-page":"174","article-title":"The human heart \u03b2\u2010adrenergic receptors. II. Coupling of \u03b22\u2010adrenergic receptors with the adenylate cyclase system","volume":"24","author":"Waelbroeck M","year":"1983","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339402200110"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.5.C1665"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122012670"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0303"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/374640a0"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.10043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.10043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T10:40:24Z","timestamp":1700217624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.10043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1002\/bdrb.10043"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.10043","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}