{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:32:22Z","timestamp":1760203942323},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T00:00:00Z","timestamp":1077580800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Supernumerary ribs (SNR) of differing sizes are commonly observed in rodent developmental toxicity studies, and the significance of treatment\u2010related increases in SNR in standard studies has been contentious. We induced dose\u2010related increases in SNR in fetal CD\u20101 mice by treating on gestation days 7\u20138 with benomyl (BEN; 0, 75, 150\u2009mg\/kg\/d), dinoseb (DIN; 0, 30, 50\u2009mg\/kg\/d); 2\u2010methoxyethanol (2\u2010ME; 0, 75, 150\u2009mg\/kg\/d), or valproic acid (VPA; 0, 125, 250\u2009mg\/kg\/d). Incidences of SNR were 9.3\u201327.6% in controls and 19.3\u201384.4% in the high dosage groups. SNR length showed a bimodal distribution with peaks at 0.3\u20130.4\u2009mm and 0.9\u20131.1\u2009mm in both treated and control groups. Based on length distributions, we used an actual length of 0.6\u2009mm to separate short (rudimentary) from long (extra) SNR. DIN, 2\u2010ME, and VPA induced a dose\u2010related increase of extra ribs, while the incidence of rudimentary ribs remained at control levels. There was no apparent correlation of the presence of either type of SNR in a fetus and the occurrence of other anomalies. These data support the idea that extra and rudimentary SNR may reflect separate developmental phenomena, and should be considered and reported separately in developmental toxicity studies for risk assessment.<jats:italic>Birth Defects Res B<\/jats:italic> 71:17\u201325, 2004. Published 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.10055","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T20:25:46Z","timestamp":1077827146000},"page":"17-25","source":"Crossref","is-referenced-by-count":14,"title":["Chemically induced supernumerary lumbar ribs in CD\u20101 mice: Size distribution and dose response"],"prefix":"10.1002","volume":"71","author":[{"given":"John M.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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