{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:51Z","timestamp":1786977111673,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    The triazole derivative, triadimefon (FON), induces branchial arch abnormalities in post\u2010implantation rat embryos cultured in vitro, and cranio\u2010facial malformations in mouse fetuses. Ectopic maxillary cartilage has been also described as a typical FON\u2010related malformation. This work studies the morphogenesis of the ectopic cartilage in rat embryos and fetuses exposed in vivo to FON during the early postimplantation period.\n                    <jats:bold>METHODS:<\/jats:bold>\n                    Pregnant rats were treated with 0, 250, and 500\u2009mg\/kg FON on Day 9.5 of pregnancy (D9.5) and sacrificed at term (D20), during the early fetal period (D17) or at different embryogenetic periods (D10, D11, D12). The skeleton was examined after stain of bone and cartilage or of cartilage alone respectively at term or at D17. The neural crest cell (NCC) migration and compaction was investigated at D10 and D11 and the cranial nerve organization described at D12.\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Triadimefon is teratogenic in rats under the chosen experimental conditions. The malformations were at the level of the cranio\u2010facial and axial skeleton at term and of the hindbrain nerves in embryos. A NCC abnormal migration and compaction was observed at the level of the first branchial arch: in FON\u2010exposed embryos NCC were detected at the level of both maxillary and mandibular processes, whereas control embryos showed the immunostained tissue only at the level of the mandibular bud.\n                    <jats:bold>CONCLUSIONS:<\/jats:bold>\n                    The pathogenic pathway, proposed to explain the ectopic cartilage, is the displacement of part of the NCC\u2010derived tissues at the maxillary region of the first branchial arch.\n                    <jats:italic>Birth Defects Res (Part B)<\/jats:italic>\n                    . \u00a9 2006 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/bdrb.20097","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T16:26:48Z","timestamp":1166804808000},"page":"2-11","source":"Crossref","is-referenced-by-count":17,"title":["Antifungal triazole derivative triadimefon induces ectopic maxillary cartilage by altering the morphogenesis of the first branchial arch"],"prefix":"10.1002","volume":"80","author":[{"given":"Francesca","family":"Di Renzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Broccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminio","family":"Giavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Menegola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.08.046"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1671"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012597951-1\/50023-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1242\/dev.127.12.2751","article-title":"Analysis of cranial neural crest migratory pathways in axolotl using cell markers and transplantation","volume":"127","author":"Epperlein 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