{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:03:50Z","timestamp":1781712230518,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T00:00:00Z","timestamp":1170979200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold>To test whether the differentiating embryo is susceptible to the teratogenic effects of the nitric oxide (NO) synthesis inhibitor N<jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine methyl ester (<jats:sc>L<\/jats:sc>\u2010NAME).<jats:bold>METHODS:<\/jats:bold>ICR\u2010(CD\u20101) mice received a single intraperitoneal injection of<jats:sc>L<\/jats:sc>\u2010NAME at 90, 150, or 300\u2009mg\/kg on Gestation Day (GD) 8 or 9. Controls were treated with vehicle on GD 8 and 9. Teratological assessments were carried out near term (GD 18).<jats:bold>RESULTS:<\/jats:bold>Maternal treatment with a single dose of<jats:sc>L<\/jats:sc>\u2010NAME at 150 or 300\u2009mg\/kg on either GD 8 or 9 produced axial skeletal defects in the ICR (CD\u20101) mouse fetuses. Other treatment\u2010related effects included increased embryo lethality and fetal growth restriction.<jats:bold>CONCLUSIONS:<\/jats:bold>This study provides evidence that in utero exposure to<jats:sc>L<\/jats:sc>\u2010NAME can affect organogenesis of the axial skeleton.<jats:italic>Birth Defects Res (Part B)<\/jats:italic>80:28\u201333, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20100","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T22:16:53Z","timestamp":1171059413000},"page":"28-33","source":"Crossref","is-referenced-by-count":5,"title":["Production of axial skeletal malformations with the nitric oxide synthesis inhibitor N<sup>G<\/sup>\u2010nitro\u2010<scp>L<\/scp>\u2010arginine methyl ester (<scp>L<\/scp>\u2010NAME) in the mouse"],"prefix":"10.1002","volume":"80","author":[{"given":"Gian 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