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Although they tend to be regarded as minor effects, they can be quite sensitive and consequently may influence the study lowest\u2010observed\u2010adverse\u2010effect levels (LOAELs), and thus, impact classification, labeling, and risk assessment. In this study, we review the underlying mechanisms of these skeletal variations, evaluate different scenarios in which they have been observed, offer guidance for their interpretation, and comment on their use for risk assessment. Both minor delays in ossification and wavy ribs seem to be readily repairable via postnatal skeletal remodeling, are not mechanistically linked to malformation, and often are seen in the presence of maternal or fetal toxicity. As such, these minor variations would not generally be considered adverse in and of themselves but should be interpreted in the context of other maternal and fetal findings, information available on normal skeletogenesis patterns, mode of action of the test agent, and historical control incidence using a weight of evidence approach. <jats:italic>Birth Defects Res 80<\/jats:italic>:473\u2013496, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20133","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T23:16:31Z","timestamp":1198278991000},"page":"473-496","source":"Crossref","is-referenced-by-count":85,"title":["Interpretation of skeletal variations for human risk assessment: delayed ossification and wavy ribs"],"prefix":"10.1002","volume":"80","author":[{"given":"Edward W.","family":"Carney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole 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