{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:26:26Z","timestamp":1791890786225,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:00:00Z","timestamp":1224028800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Published studies for reproductive and developmental toxicity conducted with isopropanol have been conducted by the inhalation and oral gavage routes of administration. Interpretation of the data from these studies has resulted in discussions regarding NOAELs and additional benchmark dose modeling publications. Unpublished reproductive and developmental toxicity studies administered in the drinking water were also conducted by BIBRA, and the results of those studies are presented here. In addition, all of the reproductive and developmental toxicity studies conducted with isopropanol are summarized and evaluated for concordance of effects and NOAELs. Endpoints of concern for regulatory agencies were decreases in male mating index and reductions in postnatal pup survival. Original study reports were evaluated and data collated to address these two endpoints, and the data summarized. Data are presented suggesting that there were technical problems in the study that implied a decrease in male mating index, and based on the results from the drinking water studies, the weight of evidence suggests that isopropanol does not affect male mating or fertility at dose levels of up to 1000\u2009mg\/kg\/day. The weight of evidence suggests that isopropanol can cause decreases in postnatal pup survival following oral gavage administration of 1000\u20131200\u2009mg\/kg\/day to the dams. The NOAEL for this endpoint with oral gavage administration was 700\u2009mg\/kg\/day. Indications of maternal toxicity were also an important predictor for decreased postnatal survival. Decreased postnatal pup survival was also noted in the drinking water studies with isopropanol with a LOAEL of 2278\u2009mg\/kg\/day and a NOAEL of 1947\u2009mg\/kg\/day. <jats:italic>Birth Defects Res (Part B)<\/jats:italic> 83:459\u2010476, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20167","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T23:23:16Z","timestamp":1224112996000},"page":"459-476","source":"Crossref","is-referenced-by-count":8,"title":["Review of reproductive and developmental toxicity studies with isopropanol"],"prefix":"10.1002","volume":"83","author":[{"given":"Willem D.","family":"Faber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Pavkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Gingell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1998.1226"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550150210"},{"key":"e_1_2_10_5_1","volume-title":"A pilot one\u2010generation study with isopropyl alcohol in rats","author":"BIBRA","year":"1986"},{"key":"e_1_2_10_6_1","unstructured":"BIBRA.1987.A teratology study with isopropyl alcohol in rats. The British Industrial Biological Research Association Carshalton Surrey. Report No. 570\/2\/86"},{"key":"e_1_2_10_7_1","unstructured":"BIBRA.1988.A single generation reproduction and embryotoxicity study with isopropyl alcohol in rats. The British Industrial Biological Research Association Carshalton Surrey. Report No. 570\/3\/86."},{"key":"e_1_2_10_8_1","unstructured":"BIBRA.1990.Investigations supplementary to studies with isopropyl alcohol. The British Industrial Biological Research Association Carshalton Surrey. Report No. 570\/4\/90."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1123"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.2284"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(1998090)18:5<373::AID-JAT522>3.0.CO;2-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2002.1540"},{"key":"e_1_2_10_13_1","unstructured":"HarrisS.1995.A review of the EPA comments regarding the study entitled \u201cA Multigeneration Rat Reproductive Study with Isopropanol.\u201d Report prepared for the Chemical Manufacturers Association Isopropanol Panel."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(88)90126-3"},{"key":"e_1_2_10_15_1","first-page":"61","article-title":"Refinements in rapid clearing technic in the KOH\u2010Alizarin Red S method for fetal bone","volume":"39","author":"Staples RE","year":"1964","journal-title":"Stain Technol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1017"},{"key":"e_1_2_10_17_1","unstructured":"TylRW.1996. Personal correspondence to Kathryn Rosica Chemical Manufacturers Association Arlington VA from Rochelle Tyl Center for Life Sciences and Toxicology Research Triangle Institute Research Triangle Park NC February 12."},{"issue":"203","key":"e_1_2_10_18_1","first-page":"43252","article-title":"Isopropanol; Final Test Rule","volume":"54","author":"U.S. EPA","year":"1989","journal-title":"Fed Reg"},{"key":"e_1_2_10_19_1","unstructured":"U.S. EPA.1992. Memorandum to Keith Cronin Chemical Testing Branch from Jennifer Seed Toxic Effects Section July 1."},{"key":"e_1_2_10_20_1","volume-title":"Environment and Birth Defects","author":"Wilson JG","year":"1973"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.20167","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.20167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:50:59Z","timestamp":1699955459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.20167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/bdrb.20167"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.20167","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}