{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:14:04Z","timestamp":1769760844361,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T00:00:00Z","timestamp":1236816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND<\/jats:bold>: <jats:italic>Scutellaria baicalensis<\/jats:italic> is a perennial herbaceous plant widely distributed in Oriental areas. Its roots, a commonly used medicinal source, reputedly calm fetuses in pregnant women; however, there is no sufficient evidence to date to assess its safety during pregnancy. This study aims to evaluate the effects of <jats:italic>S. baicalensis<\/jats:italic> aqueous extract on embryonic development in ICR mice. <jats:bold>METHODS<\/jats:bold>: Aqueous extract of <jats:italic>S. baicalensis<\/jats:italic> roots was prepared in accordance with clinical application. Pregnant mice were randomly divided into four groups, i.e., mice treated by gavage with water as negative control, with aqueous extract of 2 (1.8 times of human daily dose), 8 or 32\u2009g\/kg\/day from gestation day (Gd) 6 to 15 as low\u2010, middle\u2010, and high\u2010dose groups, respectively. The parameters of live and dead fetuses, resorptions, external and skeletal malformed fetuses, maternal body weight, maternal liver, kidneys, and heart weights were evaluated on Gd 18. <jats:bold>RESULTS<\/jats:bold>: There was no significant difference in fetal parameters among four groups. Maternal absolute liver and kidneys weights in the high\u2010dose group were significantly higher than those in negative control (<jats:italic>p<\/jats:italic>&lt;0.05). Relative liver and kidneys weights in this group were significantly higher than those in any other group (<jats:italic>p<\/jats:italic>&lt;0.05). <jats:bold>CONCLUSIONS<\/jats:bold>: Oral administration of aqueous extract of <jats:italic>S. baicalensis<\/jats:italic> roots at or below 32\u2009g\/kg\/day to ICR mice during organogenesis did not cause significant fetal external or skeletal malformations. However, 32\u2009g\/kg\/day presented potential maternal toxicity. <jats:italic>Birth Defects Res (Part B)<\/jats:italic>86: 79\u201084, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20186","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T19:01:13Z","timestamp":1236884473000},"page":"79-84","source":"Crossref","is-referenced-by-count":29,"title":["The effects of <i>Scutellaria baicalensis<\/i> extract on embryonic development in mice"],"prefix":"10.1002","volume":"86","author":[{"given":"Xiao Ying","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lok 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