{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:39:55Z","timestamp":1760204395390},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T00:00:00Z","timestamp":1251417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> An increasing number of women are being vaccinated during child\u2010bearing years, including vaccination with BioThrax<jats:sup>\u00ae<\/jats:sup> (Anthrax Vaccine Adsorbed, or AVA). As only a limited number of studies exist in humans that have examined the effects of AVA on reproductive health, this study was conducted in order to evaluate the impact AVA vaccination may have on pregnant female rabbits and their offspring. <jats:bold>METHODS:<\/jats:bold> Two hundred female rabbits were vaccinated with saline, adjuvant, or AVA twice prior to mating and on one of two occasions during gestation, in order to have exposure to the antigen during organogenesis. Blood samples were collected from does and fetuses\/kits to assess the development and in utero transfer of antibodies to <jats:italic>Bacillus anthracis<\/jats:italic>protective antigen (anti\u2010PA IgG). Half of the does underwent Caesarean\u2010sectioning on gestation day 29 and a gross necropsy was performed on both the does and their fetuses. The other half were allowed to naturally deliver and gross necropsy of the does and their kits was performed on lactation day 29. <jats:bold>RESULTS:<\/jats:bold> ELISA results showed that anti\u2010PA IgG was generated by the does and passed to the fetuses\/kits at detectable levels. <jats:bold>CONCLUSIONS:<\/jats:bold> AVA directly, or indirectly through the production of anti\u2010PA IgG, did not appear to have an adverse effect on the pregnant females or their offspring, as measured by mating and fertility indices, natural delivery observations, clinical signs, gross lesions, in utero growth and survival, morphological development, or kit viability. <jats:italic>Birth Defects Res (Part B)<\/jats:italic> 86:370\u2013376, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20205","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T17:29:52Z","timestamp":1251480592000},"page":"370-376","source":"Crossref","is-referenced-by-count":12,"title":["Reproductive toxicity of BioThrax<sup>\u00ae<\/sup> in rabbits"],"prefix":"10.1002","volume":"86","author":[{"given":"Cynthia","family":"Franco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Morseth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Thomas","family":"Waytes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,28]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"The immunobiology of mammalian reproduction","author":"Beer AE","year":"1976"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.07.965"},{"key":"e_1_2_5_4_1","first-page":"562","article-title":"Recent increases in the incidences of skull, lung and rib alterations in vehicle control New Zealand White rabbits","volume":"6","author":"Christian MS","year":"1987","journal-title":"J Am Coll Toxicol"},{"key":"e_1_2_5_5_1","volume-title":"The basis of toxicity testing","author":"Ecobichon DJ","year":"1997"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00234-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn159"},{"key":"e_1_2_5_8_1","first-page":"A37","article-title":"Detection of visceral alterations in mammalian fetuses","volume":"9","author":"Staples RE","year":"1974","journal-title":"Teratology"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00611-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.12.1556"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.20205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.20205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T21:51:54Z","timestamp":1699912314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.20205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,28]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/bdrb.20205"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.20205","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,28]]}}}