{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:51:38Z","timestamp":1792083098551,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T00:00:00Z","timestamp":1258329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold>Nutrients such as folic acid and selenium are decreased in dams exposed to ethanol during gestation and lactation, affecting their metabolism, antioxidant balance, and the future health of their progeny. We will study whether the supplementation of the maternal diet with folate and selenium can prevent ethanol\u2010induced oxidative liver disorders in the offspring.<jats:bold>METHODS:<\/jats:bold>Dams were randomised into four groups: control, alcohol, alcohol+folic acid+Se, and control+folic acid+Se. We determined selenium by graphite\u2010furnace atomic absorption and antioxidant enzyme activities, lipid peroxidation, and protein carbonyl by spectrophotometry in the offspring.<jats:bold>RESULTS:<\/jats:bold>Alcohol increased serum Se levels and glutathione peroxidase (GPx) activity. However, in the liver of pups from ethanol\u2010exposed dams a decrease in selenium was provoked and GPx activity increased with the double supplementation. Glutathione reductase (GR) and catalase (CAT) activities increased with ethanol, while double supplementation significantly decreased the GR activity. The supplemented diet reduced the protein peroxidation found in ethanol pups.<jats:bold>CONCLUSIONS:<\/jats:bold>These results suggest that folic acid+Se could be effective in neutralising the damage of ethanol consumption in pups since it prevents peroxidation protein products.<jats:italic>Birth Defects Res (Part B)<\/jats:italic>86:490\u2013495, 2009.\u2003\u2003\u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20211","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T16:06:29Z","timestamp":1258387589000},"page":"490-495","source":"Crossref","is-referenced-by-count":35,"title":["Dietary selenium plus folic acid as an antioxidant therapy for ethanol\u2010exposed pups"],"prefix":"10.1002","volume":"86","author":[{"given":"M. L.","family":"Ojeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nogales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jotty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Barrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029903006058"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00088-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"1","author":"Beers RF","year":"1952","journal-title":"J Biol Chem"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760100300011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.9.2907"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"e_1_2_5_8_1","first-page":"213","volume-title":"CRC handbook of methods for oxygen radical research","author":"Fridovich I","year":"1985"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00321-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.8.2367S"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2007.11.003"},{"key":"e_1_2_5_12_1","first-page":"413","article-title":"Control of diets in laboratory animals experimentation","volume":"49","author":"ILAR: Institute of Laboratory Animal Resources","year":"1979","journal-title":"Nutr Abstr Rev"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"1","author":"Lowry OH","year":"1951","journal-title":"J Biol Chem"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2003.09.010"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-001-0421-6"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn044"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agp004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02490-9"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33041-7"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90197-9"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0090-9556(25)08963-9","article-title":"Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite","volume":"19","author":"Sohn O","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04606.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.01.012"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.6.1122"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00147.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl024"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03754.x"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.20211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.20211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T07:48:04Z","timestamp":1739432884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.20211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1002\/bdrb.20211"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.20211","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}