{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:15:52Z","timestamp":1760645752357},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T00:00:00Z","timestamp":1272240000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> Omega\u20106 fatty acids are important to fetal development. However, during gestation\/lactation, these fatty acids may contribute toward the development of fat tissue. Omega\u20109 fatty acids are associated with a reduction in serum lipids and protection from liver disease. <jats:bold>OBJECTIVES:<\/jats:bold> The present study investigated the effect of the maternal intake of omega\u20106 and omega\u20109 in hypercholesterolemic mothers on the liver of the offspring. <jats:bold>METHODS:<\/jats:bold> LDL receptor\u2013deficient mice were fed a diet rich in either omega\u20106 (E6D) or omega\u20109 (E9D) for 45 days prior to mating and until the birth of the offspring, evaluating the effect on the offspring liver in comparison to a standard diet (STD). <jats:bold>RESULTS:<\/jats:bold> Mothers fed with the E6D experienced an increase in total cholesterol (TC) and the offspring exhibited an increase in TC, hepatic triglycerides (TG), and CC\u2010chemokine ligand (CCL)2\/monocyte chemoattractant protein (MCP)\u20101 as well as a reduction in HDL. Histological analysis on this group revealed steatosis, leukocyte infiltrate, and increased CCL2\/MCP\u20101 expression. The ultrastructural analysis revealed hepatocytes with lipid droplets and myofibroblasts. The offspring of mothers fed the standard diet exhibited low serum TC, but microvesicular steatosis was observed. The offspring of mothers fed the E9D exhibited lower serum and hepatic TG as well as higher LDL in comparison to the other diets. The histological analyses revealed lower steatosis and leukocyte infiltrate. <jats:bold>CONCLUSIONS:<\/jats:bold> The findings suggest that hypercholesterolemic mothers with a diet rich in omega\u20106 fatty acids predispose their offspring to steatohepatitis, whereas a diet rich in omega\u20109 has a protective effect. <jats:italic>Birth Defects Res (Part B)<\/jats:italic> 89:164\u2013170, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20240","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T12:51:08Z","timestamp":1272286268000},"page":"164-170","source":"Crossref","is-referenced-by-count":10,"title":["Effect of maternal diet rich in omega\u20106 and omega\u20109 fatty acids on the liver of LDL receptor\u2010deficient mouse offspring"],"prefix":"10.1002","volume":"89","author":[{"given":"Dil\u00eania","family":"De Oliveira Cipriano 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