{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:18:05Z","timestamp":1791091085979,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T00:00:00Z","timestamp":1316044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to determine whether in utero exposure to Bisphenol A (BPA) induced reproductive tract abnormalities in the adult male testis. Using the C57\/Bl6 mouse, we examined sex\u2010organ weights, anogenital distance, and testis histopathology in adult males exposed in utero via oral gavage to sesame oil, 50\u2009\u00b5g\/kg BPA, 1000\u2009\u00b5g\/kg BPA, or 2\u2009\u00b5g\/kg diethylstilbestrol (DES) as a positive control from gestational days 10 to 16. No changes in sperm production or germ cell apoptosis were observed in adult testes after exposure to either chemical. Adult mRNA levels of genes associated with sexual maturation and differentiation, <jats:italic>GATA4<\/jats:italic> and <jats:italic>ID2<\/jats:italic>, were significantly lower only in DES\u2010exposed testes. In summary, the data indicate no gross alterations in spermatogenesis after in utero exposure to BPA or DES. At the molecular level, in utero exposure to DES, but not BPA, leads to decreased mRNA expression of genes associated with Sertoli cell differentiation. <jats:italic>Birth Defects Res (Part B)<\/jats:italic> 92:526\u2013533, 2011. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20336","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T22:35:05Z","timestamp":1316126105000},"page":"526-533","source":"Crossref","is-referenced-by-count":58,"title":["Effects of in utero exposure to Bisphenol A or diethylstilbestrol on the adult male reproductive 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