{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:46Z","timestamp":1761101986890},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> <jats:italic>Ipomoea carnea<\/jats:italic> (<jats:italic>I. carnea<\/jats:italic>) is a poisonous plant found in Brazil and other tropical countries that often poison livestock. The plant contains the alkaloids calystegines and mainly swainsonine, which inhibit cellular enzymes and cause systematic cell death. The objective of this study was to evaluate the perinatal effects of <jats:italic>I. carnea<\/jats:italic> in goats. <jats:bold>Methods:<\/jats:bold> Forty\u2010seven pregnant goats were randomly allocated into 5 treatment groups and given the following doses (g\/kg BW) of <jats:italic>I. carnea<\/jats:italic>: 0 (IC0), 1.0 (IC1), 3.0 (IC3), 5.0 (IC5) and 7.5 (IC7). The treatment animals were given fresh <jats:italic>I. carnea<\/jats:italic> from day 27 of gestation to parturition. Weight gains and serum biochemistry were evaluated. Fetuses were evaluated using ultrasonographic measurements. <jats:bold>Results:<\/jats:bold> Goats from the IC7 group showed clinical signs of poisoning. Ultrasound examination revealed that <jats:italic>I. carnea<\/jats:italic> feeding in all treatment groups reduced fetal movement compared to the controls. There was an increase in the total number of birth defects (retrognathia and arthrogyposis) in the IC7 and IC5 groups compared to the controls. <jats:bold>Conclusion:<\/jats:bold> The results show that <jats:italic>I. carnea<\/jats:italic> has teratogenic potential in goats. In addition, ultrasounds were useful in evaluating fetotoxicity and teratogenicity. Birth Defects Res (Part B) 00:1\u20137, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.21017","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T20:43:32Z","timestamp":1338324212000},"page":"289-295","source":"Crossref","is-referenced-by-count":10,"title":["The Use of Ultrasonography to Study Teratogenicity in Ruminants: Evaluation of <i><scp>I<\/scp>pomoea carnea<\/i> in Goats"],"prefix":"10.1002","volume":"95","author":[{"given":"Andr\u00e9 T.","family":"Gotardo","sequence":"first","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno H.","family":"Schumaher","sequence":"additional","affiliation":[{"name":"Superior Baptist School of the Amazon (ESBAM) School of Veterinary Medicine Manaus 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