{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:29:05Z","timestamp":1767835745542,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment\u2010free period in control and 30, 60, and 180\u00a0mg\/kg dose groups (<jats:italic>n<\/jats:italic> = 22\/group). Compound A in a dose\u2010dependent manner induced various degrees of spermatogenic alterations compatible with Sertoli cells being the primary target, for example, inter\u2010 and intracellular Sertoli cell vacuolization and altered cellular morphology followed by germ cell degeneration and marked reduction of epididymidal sperm numbers. Blood\u2013testis barrier remained intact (electron microscopy and hyperosmotic fixation test) until germ cells disappeared. Mating behavior and weights of androgen\u2010dependent prostate and seminal vesicles remained unaffected. Inhibin B levels correlated only with moderate to severe spermatogenic alterations. Ten animals with inhibin B levels below detection limit were encountered and five of these animals were fertile in week 19 but following 19 weeks without treatment, another five animals were rendered infertile and inhibin B levels remained undetectable. In the rat, inhibin B only reflects major spermatogenic alterations and markedly reduced inhibin B levels might indicate irreversibility of these alterations and even infertility.<\/jats:p>","DOI":"10.1002\/bdrb.21046","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T17:37:21Z","timestamp":1359049041000},"page":"91-103","source":"Crossref","is-referenced-by-count":16,"title":["Inhibin B as a Marker of Sertoli Cell Damage and Spermatogenic Disturbance in the Rat"],"prefix":"10.1002","volume":"98","author":[{"given":"Tamara","family":"Pfaff","sequence":"first","affiliation":[{"name":"Preclinical Drug Safety AiCuris GmbH &amp; Co. KG  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Covance Harrogate  England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Anatomy, \u2010Histology and \u2010Embryology, University Giessen  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard F.","family":"Weinbauer","sequence":"additional","affiliation":[{"name":"Covance Laboratories GmbH  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00224733"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1991.tb00208.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","unstructured":"BoekelheideK JohnsonKJ RichburgJH.2004.Sertoli cell toxicants. In:SkinnerMK Grisworld MD editors.Sertoli cell biology.","DOI":"10.1016\/B978-012647751-1\/50021-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(83)90082-5"},{"key":"e_1_2_5_6_1","first-page":"xx","article-title":"Summary of the HESI Consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat","author":"Chapin RE","year":"2013","journal-title":"Birth Def Res B"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711390307"},{"key":"e_1_2_5_8_1","first-page":"xx","article-title":"Analytic evaluation of a human ELISA kit for measurement of inhibin B in rat samples","author":"Coulson M","year":"2013","journal-title":"Birth Def Res B"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(87)90056-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1972.52.1.198"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolreprod\/3.3.308"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq210"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.05.010"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.01.010"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.6.1771"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.106.002295"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod28.4.1007"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701481931"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092030408"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1995.tb01744.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00256951"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0700635"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001840302"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-2005-1109"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.21046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.21046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T11:50:49Z","timestamp":1694519449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.21046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/bdrb.21046"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.21046","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]}}}