{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:05:26Z","timestamp":1762866326251},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>S\u201053482 is an <jats:italic>N<\/jats:italic>\u2010phenylimide herbicide and shows a remarkable species difference in developmental toxicity between rats and rabbits. The herbicide produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats, but not in rabbits. Our objective in this study was to investigate differences in developmental toxicity among <jats:italic>N<\/jats:italic>\u2010phenylimide compounds structurally similar to S\u201053482 to better characterize the developmental effects of S\u201053482 on rat and rabbit embryos as part of research investigation to elucidate a mechanism of rat developmental toxicity produced by S\u201053482. This paper is part of a series of studies to be published serially.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>S\u201023121 or S\u201023031, both of which are structurally similar to S\u201053482, was orally administered to rats and rabbits during fetal organogenesis. Fetuses were obtained by cesarian section and examined for external, visceral, and skeletal alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>S\u201023121 produced the similar pattern of developmental toxicity such as embryolethality, teratogenicity, and growth retardation in rats. In contrast, S\u201023031 showed no developmental toxicity at 1500 mg\/kg. Rabbits were insensitive to all study compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The difference in developmental toxicity in rats was striking among <jats:italic>N<\/jats:italic>\u2010phenylimide herbicides. The mechanism of action of developmental toxicity by S\u201053482 should account for the compound\u2010specific difference as well as species difference between rats and rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdrb.21087","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T18:57:05Z","timestamp":1388775425000},"page":"437-444","source":"Crossref","is-referenced-by-count":7,"title":["Difference in Developmental Toxicity Among Structurally Similar <i>N<\/i>\u2010Phenylimide Herbicides in Rats and Rabbits"],"prefix":"10.1002","volume":"98","author":[{"given":"Satoshi","family":"Kawamura","sequence":"first","affiliation":[{"name":"Environmental Health Science Laboratory Sumitomo Chemical Co., Ltd.  Konohana\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terushige","family":"Kato","sequence":"additional","affiliation":[{"name":"Environmental Health Science Laboratory Sumitomo Chemical Co., Ltd.  Konohana\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Kannan","sequence":"additional","affiliation":[{"name":"Environmental Health Science Laboratory Sumitomo Chemical Co., Ltd.  Konohana\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Fantel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Washington  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx0502241"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1016\/S0021-9258(18)69000-3","article-title":"Organization of the terminal two enzymes of the heme biosynthetic pathway","volume":"263","author":"Ferreira GC","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420410106"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1995.tb00306.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0317"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199611)54:5<237::AID-TERA4>3.0.CO;2-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80186-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf950678b"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf960312e"},{"key":"e_1_2_6_11_1","first-page":"65","volume-title":"Methods for detection of environmental agents that produce congenital defects","author":"Schumacher HJ","year":"1975"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0048-3575(91)90095-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf980516q"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf981007r"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259309059399"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259309059423"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.21087","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.21087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:30:36Z","timestamp":1696606236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.21087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/bdrb.21087"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.21087","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}