{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:57:42Z","timestamp":1771495062735,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>S\u201053482 and S\u201023121 are <jats:italic>N<\/jats:italic>\u2010phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies. Our objective in this study was to investigate whether the compounds induce developmental toxicity via the dermal route, which is more relevant to occupational exposure, hence better addressing human health risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>S\u201053482 was administered dermally to rats at 30, 100, and 300 mg\/kg during organogenesis, and S\u201023121 was administered at 200, 400, and 800 mg\/kg (the maximum applicable dose level). Fetuses were obtained by a Cesarean section and examined for external, visceral, and skeletal alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermal exposure of rats to S\u201053482 at 300 mg\/kg produced patterns of developmental toxicity similar to those resulting from oral exposure. Toxicity included embryolethality, teratogenicity, and growth retardation. Dermal administration of S\u201023121 at 800 mg\/kg resulted in an increased incidence of embryonic death and ventricular septal defect, but retarded fetal growth was not observed as it was following oral exposure to S\u201023121.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the results, S\u201053482 and S\u201023121 were teratogenic when administered dermally to pregnant rats as were the compounds administered orally. Thus, investigation of the mechanism and its human relevancy become more important.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdrb.21103","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T21:33:38Z","timestamp":1397856818000},"page":"162-167","source":"Crossref","is-referenced-by-count":7,"title":["Dermal Developmental Toxicity of <i>N<\/i>\u2010Phenylimide Herbicides in Rats"],"prefix":"10.1002","volume":"101","author":[{"given":"Satoshi","family":"Kawamura","sequence":"first","affiliation":[{"name":"Environmental Health Science Laboratory Sumitomo Chemical Co., Ltd  Konohana\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terushige","family":"Kato","sequence":"additional","affiliation":[{"name":"Environmental Health Science Laboratory Sumitomo Chemical Co., Ltd  Konohana\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Nakaoka","sequence":"additional","affiliation":[{"name":"Environmental Health Science Laboratory Sumitomo Chemical Co., Ltd  Konohana\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Fantel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"703","volume-title":"Dermatotoxicology","author":"Barlow SM.","year":"1991"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(82)80117-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(83)90104-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.845769"},{"key":"e_1_2_7_6_1","first-page":"23","article-title":"A microdissection method for detecting thoracic visceral malformations in mouse and rat fetuses","volume":"14","author":"Nishimura K.","year":"1974","journal-title":"Cong Anom"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1990.tb00498.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1995.tb00306.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0317"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199611)54:5<237::AID-TERA4>3.0.CO;2-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.21087"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(90)90218-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80186-3"},{"key":"e_1_2_7_14_1","first-page":"272","volume-title":"Teratology: principles and techniques","author":"Wilson JG.","year":"1965"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.21103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.21103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:30:43Z","timestamp":1696617043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.21103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/bdrb.21103"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.21103","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}