{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:18:59Z","timestamp":1767856739811,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>This study is the first to investigate the effects of different doses of nandrolone decanoate (ND) upon uterine tissue and fertility, and if the reproductive alterations can be restored after cessation of the treatment. Wistar female rats were treated with ND at doses of 1.87, 3.75, 7.5, and 15\u00a0mg\/kg body weight, diluted in vehicle (<jats:italic>n<\/jats:italic> = 30\/group), or received only mineral oil (control group, <jats:italic>n<\/jats:italic> = 45). The animals were divided into three periods of study: ND\u2010treated receiving a daily subcutaneous injection for 15 consecutive days (1), and treatment with ND followed by 30\u2010day recovery (2), and 60\u2010day recovery (3). At the end of each period, five females per group were induced to death to histopathological analysis and the others were allowed to fertility evaluation (at 19th gestational day). Animals that received ND followed by 30\u2010day recovery exhibited persistent diestrous and marked suppression of reproductive capacity. Conversely, after 60\u2010day recovery, only lowest doses females (1.87 and 3.75\u00a0mg\/kg) exhibited restoration of normal estrous cyclicity. Uterine weights were increased after ND treatment similarly to that of the controls after 60\u2010day recovery. The ND\u2010treated groups showed histopathological changes in the endometrium, myometrium, and perimetrium, and an increase in the thickness of both muscular and serous layers. Notably, the recovery of uterine tissue after ND treatment was dose\u2010 and period\u2010dependent. We reported that administration of ND promoted damage in uterine tissue and fertility of rats, and the recovery periods were insufficient to restore all of the side effects caused by ND under a dose\u2010dependent response<\/jats:p>","DOI":"10.1002\/bdrb.21104","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T21:33:38Z","timestamp":1397856818000},"page":"168-177","source":"Crossref","is-referenced-by-count":20,"title":["Dose\u2010Dependent Effects and Reversibility of the Injuries Caused by Nandrolone Decanoate in Uterine Tissue and Fertility of Rats"],"prefix":"10.1002","volume":"101","author":[{"given":"Larissa Berloffa","family":"Belardin","sequence":"first","affiliation":[{"name":"Faculty of Sciences and Letters Department of Biological Sciences Univ Estadual Paulista\u2014UNESP  Assis S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Augusto","family":"Sim\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Letters Department of Biological Sciences Univ Estadual Paulista\u2014UNESP  Assis S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Adan Ara\u00fajo","family":"Leite","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Letters Department of Biological Sciences Univ Estadual Paulista\u2014UNESP  Assis S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Gustavo de Almeida","family":"Chuffa","sequence":"additional","affiliation":[{"name":"Department of Anatomy Institute of Biosciences Univ Estadual Paulista\u2014UNESP  Botucatu S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Cristina Cherici","family":"Camargo","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Letters Department of Biological Sciences Univ Estadual 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