{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:30:36Z","timestamp":1740137436407,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011531","name":"The University of Alabama","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011531","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Diabetes mellitus is a growing concern worldwide and leads to multiple complications during pregnancy. Pharmacologic doses of chromium (Cr) have been linked with improving insulin sensitivity and other positive benefits in the treatment of diabetes in animal models. By using streptozotocin induced hyperglycemia in female CD\u20101 mice, reproductive outcomes of diabetic and chromium\u2010dosed diabetic females were examined. After dosing 10 mg\/kg Cr in the form of triaqua\u2010\u03bc<jats:sub>3<\/jats:sub>\u2010oxo\u2010hexa\u2010\u03bc\u2010propionatotrichromium(III) chloride or Cr3 during gestation days 8\u201316 (GD8\u2013GD16), all females were sacrificed on gestation day 17 (GD17) and examined for maternal weight gain. The fetuses were examined for gross malformations and for skeletal malformations. The offspring of Cr3\u2010dosed females tended to have a reduction in the incidence of supernumerary ribs. While hyperglycemia still had negative impacts on the health of dams and their offspring, administration of Cr led to an apparent trend in the reduction in the number of malformations and incidence of supernumerary ribs compared to those of untreated diabetic mothers<\/jats:p>","DOI":"10.1002\/bdrb.21139","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T01:33:22Z","timestamp":1432085602000},"page":"65-70","source":"Crossref","is-referenced-by-count":1,"title":["The Potential of Cr3 [Triaqua\u2010\u03bc<sub>3<\/sub>\u2010Oxo\u2010Hexa\u2010\u03bc\u2010Propionatotrichromium(III) Chloride] to Reduce Birth Defects in the Offspring of Diabetic CD\u20101 Mice"],"prefix":"10.1002","volume":"104","author":[{"given":"Johnathan D.","family":"Keith","sequence":"first","affiliation":[{"name":"Department of Biological Sciences The University of Alabama  Tuscaloosa 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