{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:46:11Z","timestamp":1758969971753},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chungcheong Leading Industry Promotion Project of the Korean Ministry of Knowledge Economy","award":["R0000557"],"award-info":[{"award-number":["R0000557"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The pharmacotoxicology impacts of dietary supplements taken at the time of pregnancy have remained alarming since women are the frequent herbal medicine users in many countries as a complement to the conventional pregnancy management. The use of herbal medicines and diet supplements in expectant mothers linked closely to the health of the childbearing mothers and the fetuses where the lack of developmental safety data imposes a challenge to make the right choices. Here, we describe the potential adverse effects of UP446, a standardized bioflavonoid composition from the roots of <jats:italic>Scutellaria baicalensis<\/jats:italic> and the heartwoods of <jats:italic>Acacia catechu<\/jats:italic>, on embryo\u2010fetal development following maternal exposure during the critical period of major organogenesis in rabbits and rats. Pregnant dams were treated orally with UP446 at doses of 250, 500, and 1000 mg\/kg\/day during gestation. The number of resorptions, implantations, litter size, body weights, and skeletal development was evaluated. Maternal food intake and body, tissue, and placenta weight were also assessed. There were no statistically significant differences in implantation, congenital malformation, embryo\u2010fetal mortalities, and fetuses sex ratios in all dosing groups of both species. Therefore, the no observed adverse effect level of UP446 was considered to be greater than 1000 mg\/kg in both the maternal and fetus in both species<\/jats:p>","DOI":"10.1002\/bdrb.21150","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T01:09:29Z","timestamp":1440464969000},"page":"141-152","source":"Crossref","is-referenced-by-count":7,"title":["Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446\u2010Part I: Effects on Embryo\u2010Fetal Development in New Zealand White Rabbits and Sprague Dawley Rats"],"prefix":"10.1002","volume":"104","author":[{"given":"Mesfin","family":"Yimam","sequence":"first","affiliation":[{"name":"Unigen Inc  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Unigen Inc., Dongnam\u2010Gu  Cheonan\u2010Si Chungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eu\u2010Jin","family":"Hyun","sequence":"additional","affiliation":[{"name":"Unigen Inc., Dongnam\u2010Gu  Cheonan\u2010Si Chungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Jia","sequence":"additional","affiliation":[{"name":"Unigen Inc  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00322.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.0010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4514.2007.00142.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.255"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1142\/9789814503181_0057"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20594"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1128(200009)20:5<323::AID-MED1>3.0.CO;2-A"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.11.002"},{"key":"e_1_2_7_10_1","unstructured":"JiaQ.2009.Formulation of a mixture of Free\u2010B\u2010ring flavonoids and flavans as a therapeutic agent. 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