{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:09:19Z","timestamp":1783598959534,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81072332"],"award-info":[{"award-number":["81072332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Atrazine (ATR, 2\u2010chloro\u20104\u2010ethylamino\u20106\u2010isopropylamino\u2010s\u2010triazine) is used worldwide as a herbicide, and its presence in the environment has resulted in documented human exposure. A lack of strong evidence for genetic heritability of idiopathic Parkinson's disease has focused attention on environmental toxicants in the disease etiology, particularly agrichemicals. Parkinson's disease is associated with advanced age and is characterized by the degeneration of dopaminergic neurons, but it is unclear whether specific neuronal damage could result from insults during development. The juvenile period is particularly vulnerable to environmental agent, therefore, we evaluated the effects of a 28\u2010day exposure to ATR on the dopaminergic system in pubertal rats. Sprague\u2013Dawley rats were treated orally with ATR at 50, 100, and 200 mg\/kg bw, daily from postnatal days 27 to 54. In this study, we examined the hypothesis that pubertal exposure to ATR would disrupt the development of the nigrostriatal dopamine (DA) system. The content of DA and levodopa (L\u2010DA) were examined in striatum samples by HPLC\u2010FL, and the mRNA and protein expression of tyrosine hydroxylase, orphan nuclear hormone receptor (Nurr1), Nurr1 interacting protein (NuIP), and cyclin\u2010dependent kinase inhibitors of the Cip\u0332Kip family (p57kip2) were examined in samples of the nigrostriatum by use of fluorescence Real\u2010Time quantitative polymerase chain reaction (PCR). Exposure of juvenile rats to the high dose of ATR led to reduced levels of DA and L\u2010DA, genes expression of NuIP, Nurr1, and p57kip2 in animals<\/jats:p>","DOI":"10.1002\/bdrb.21151","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T19:45:05Z","timestamp":1441223105000},"page":"184-189","source":"Crossref","is-referenced-by-count":26,"title":["The Effect of Exposure to Atrazine on Dopaminergic Development in Pubertal Male SD Rats"],"prefix":"10.1002","volume":"104","author":[{"given":"Yan\u2010Shu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Toxicology College of Public Health Harbin Medical University  Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Toxicology College of Public Health Harbin Medical University  Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Toxicology College of Public Health Harbin Medical University  Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Toxicology College of Public Health Harbin Medical University  Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai\u2010Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Toxicology College of Public Health Harbin Medical University  Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(95)00051-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107013200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04294.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7570"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/56.2.324"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.05.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(02)00099-2"},{"key":"e_1_2_7_9_1","first-page":"29","article-title":"Factors affecting mammary tumorincidence in chlorotriazine\u2010treated female rats: hormonalproperties, dosage, and animal strain","volume":"102","author":"Eldridg JC","year":"1994","journal-title":"Environ. HeathPerspect."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.12.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2005.10.037"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.94102s1129"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.08.035"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2635658100"},{"issue":"2007","key":"e_1_2_7_15_1","first-page":"521","article-title":"Determination of low\u2010level agricultural residues in soft drinks and sports drinks by liquid chromatog\u2010raphy\/tandem mass spectrometry: single\u2010laboratory validation","volume":"90","author":"Luo Y","year":"2008","journal-title":"AOAC Int."},{"key":"e_1_2_7_16_1","first-page":"42","article-title":"Expression pattern of NuIP gene in adult mouse brain","volume":"1302","author":"Luoa Y","year":"2009","journal-title":"Brain Res Mol Brain Res"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/jaoac\/90.2.521","article-title":"Determination of low\u2010levelagricultural residues in soft drinks and sports drinks by liquid chromatog\u2010raphy\/tandem mass spectrometry: single\u2010laboratory validation","volume":"90","author":"Paske N","year":"2007","journal-title":"AOAC Int"},{"issue":"3","key":"e_1_2_7_18_1","first-page":"829","article-title":"The residual effect of imazethapyr applied in soybean tobarley and winter wheat in Romania","volume":"71","author":"Poienaru S","year":"2006","journal-title":"Commun Agric Appl Biol Sci"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.2001.4264"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7783"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl712"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.13305"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.5.660"},{"key":"e_1_2_7_24_1","unstructured":"U.S. EPA ATRAZINE in: HED's Revised Human Health Risk Assessment forthe Re\u2010registration Eligibility Decision (RED) U. S. Environmental Protection Agency Washington DC USA 2002 DP Barcodes: D272009 D281936 D281917. PC Code: 080803. Case No. 0062."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.881"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(96)00074-5"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5310.248"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.21151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.21151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.21151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:48:02Z","timestamp":1696618082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.21151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/bdrb.21151"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.21151","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}