{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:59:57Z","timestamp":1759960797600},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FAPEMAT\/Brazil","award":["453362\/2009"],"award-info":[{"award-number":["453362\/2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The aim of this study was to evaluate the effect of <jats:italic>Himatanthus sucuuba<\/jats:italic> on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant rats were randomly divided into three experimental groups as follows: Control = treated with water (vehicle), treated 250 = treated with <jats:italic>H. sucuuba<\/jats:italic> at dose 250 mg\/kg, and treated 500 = treated with <jats:italic>H. sucuuba<\/jats:italic> at dose 500 mg\/kg. The rats were orally treated, by <jats:italic>gavage<\/jats:italic>, with <jats:italic>H. sucuuba<\/jats:italic> or vehicle (water) during preimplantation and organogenic period (from gestational day 0\u201314). At day 21 of pregnancy, all rats were killed to obtain maternal\u2013fetal data. The treatment with <jats:italic>H. sucuuba<\/jats:italic> at dose of 250 mg\/kg caused reduction in placental efficiency and an increase preimplantation loss rate and placenta weight compared with the control. The treated 500 group presented a significant decrease in maternal weight gain, maternal weight gain minus gravid uterus weight, fetal weight, and placental efficiency compared with the control. In this group, there was a decrease in body weight at day 20 of pregnancy and metacarpus ossification and an increase in the preimplantation loss rate and skeletal anomalies compared with other groups. <jats:italic>Himatanthus sucuuba<\/jats:italic> extract caused intrauterine growth restriction, preimplantation loss, and developmental delay in the high doses tested<\/jats:p>","DOI":"10.1002\/bdrb.21152","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T10:19:29Z","timestamp":1444731569000},"page":"190-195","source":"Crossref","is-referenced-by-count":7,"title":["Effect of <i>Himatanthus sucuuba<\/i> in Maternal Reproductive Outcome and Fetal Anomaly Frequency in Rats"],"prefix":"10.1002","volume":"104","author":[{"given":"Thaigra","family":"de Sousa Soares","sequence":"first","affiliation":[{"name":"Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)  Barra do Gar\u00e7as Mato Grosso State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Cristina","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Research on Gynecology and Obstetrics Department of Gynecology and Obstetrics Univ Estadual Paulista_Unesp  Botucatu S\u00e3o Paulo State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma De Grava","family":"Kempinas","sequence":"additional","affiliation":[{"name":"Department of Morphology Institute of Biosciences of Botucatu Univ Estadual Paulista (Unesp)  Botucatu S\u00e3o Paulo State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Mayara Campos","family":"Resende","sequence":"additional","affiliation":[{"name":"Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)  Barra do Gar\u00e7as Mato Grosso State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida","family":"Correa dos Santos","sequence":"additional","affiliation":[{"name":"Instituto Estadual de Pesquisa do Amap\u00e1 (IEPA)  Amap\u00e1 State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9lia Akiko","family":"Hiruma\u2010Lima","sequence":"additional","affiliation":[{"name":"Department of Physiology Institute of Biosciences of Botucatu Univ Estadual Paulista (Unesp)  Botucatu S\u00e3o Paulo State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Tadeu","family":"Volpato","sequence":"additional","affiliation":[{"name":"Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)  Barra do Gar\u00e7as Mato Grosso State Brazil"},{"name":"Laboratory of Experimental Research on Gynecology and Obstetrics Department of Gynecology and Obstetrics Univ Estadual Paulista_Unesp  Botucatu S\u00e3o Paulo State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200208"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00275-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.03.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000400010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.10.046"},{"key":"e_1_2_6_7_1","volume-title":"Anomalias Cong\u00eanitas: Estudos Experimentais","author":"Damasceno DC","year":"2008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-3-20"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112461186"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8572"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209009082838"},{"key":"e_1_2_6_12_1","unstructured":"Environmental Protection Agency (EPA).1996. 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