{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:50:52Z","timestamp":1783749052261,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Public Health, University of Copenhagen"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen."},{"name":"The funders had no role in study design, data collection, data analysis, data interpretation, or writing of this article."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Previous research suggests that advanced paternal age increases the risk of musculoskeletal congenital anomalies (CAs) in offspring, but findings are inconsistent. This study aims to investigate the risk of musculoskeletal CAs according to paternal age at birth in an unselected population covering cohort of children.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>A register\u2010based prospective study of 1,605,885 children born in Denmark, 1978\u20132004, using information from record\u2010linked health and administrative registers. The association between paternal age and overall musculoskeletal CAs, limb anomalies, craniosynostosis, skeletal dysplasias, syndromic musculoskeletal CAs, and other musculoskeletal CAs were investigated by multiple logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>For overall musculoskeletal CAs, a slightly higher risk per 10\u2010year increase in paternal age was found (odds ratio [OR] = 1.06 [95% CI: 1.01\u20131.11; where CI is confidence interval]). A 26% (95% CI: 2\u201356%) excess risk was found for fathers aged 50+ years compared to fathers aged 30\u201334 years. For syndromic musculoskeletal CAs, excess risks were found for fathers aged 40+ years, compared to fathers aged 30\u201334 years (40\u201344: OR = 1.38 [95% CI: 1.01\u20131.88], 45\u201349: OR = 1.45 [95% CI: 0.89\u20132.34], 50+: OR = 1.42 [95% CI: 0.73\u20132.79]). The risks in all other subgroups of musculoskeletal CAs were increased for fathers aged 50+ years.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A slightly higher risk for overall musculoskeletal CAs in offspring was found with increasing paternal age, mainly due to an excess risk of syndromic musculoskeletal CAs for fathers aged 40+ years. While associations between paternal age 50+ years and increased risk of all subtypes of musculoskeletal CAs were indicated, advanced paternal age likely plays a minor role in the etiology of these anomalies<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdrb.21167","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T23:23:08Z","timestamp":1449789788000},"page":"273-280","source":"Crossref","is-referenced-by-count":13,"title":["Advanced Paternal Age and Risk of Musculoskeletal Congenital Anomalies in Offspring"],"prefix":"10.1002","volume":"104","author":[{"given":"Stine Kjaer","family":"Urhoj","sequence":"first","affiliation":[{"name":"Section of Social Medicine Department of Public Health University of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laust Hvas","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Section of Social Medicine Department of Public Health University of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Nybo Andersen","sequence":"additional","affiliation":[{"name":"Section of Social Medicine Department of Public Health University of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Statistical yearbook","author":"Agerskov U","year":"2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20316"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35246"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7783-9_2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8380"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088552"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2011-100372"},{"key":"e_1_2_7_10_1","unstructured":"EUROCAT.2005. 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