{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:08:54Z","timestamp":1791857334460,"version":"4.3.4"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,12,16]],"date-time":"2003-12-16T00:00:00Z","timestamp":1071532800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt C"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endochondral bone development is a fascinating story of proliferation, maturation, and death. An understanding of this process at the molecular level is emerging. In particular, significant advances have been made in understanding the role of parathyroid\u2010hormone\u2010related peptide (PTHrP), parathyroid hormone (PTH), and the PTH\/PTHrP receptor in endochondral bone development. Mutations of the PTH\/PTHrP receptor have been identified in Jansen metaphyseal chondrodysplasia, Blomstrand's lethal chondrodysplasia, and enchondromatosis. Furthermore, genetic manipulations of the PTHrP, PTH, and the PTH\/PTHrP receptor genes, respectively, have demonstrated the critical role of these proteins in regulating both the switch between proliferation and differentiation of chondrocytes, and their replacement by bone cells. A future area of investigation will be the identification of downstream effectors of PTH, PTHrP, and PTH\/PTHrP receptor activities. Furthermore, it will be of critical importance to study how these proteins cooperate and integrate with other molecules that are essential for growth plate development. Birth Defects Research (Part C) 69:352\u2013362, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrc.10028","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T09:01:48Z","timestamp":1071651708000},"page":"352-362","source":"Crossref","is-referenced-by-count":79,"title":["PTHrP, PTH, and the PTH\/PTHrP receptor in endochondral bone development"],"prefix":"10.1002","volume":"69","author":[{"given":"Ernestina","family":"Schipani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Provot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.2732"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1017802"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.10014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.12.3852"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/8792"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111092198"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388725"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.5.8386606"},{"key":"e_1_2_7_10_1","first-page":"259","volume-title":"The parathyroids.basic and clinical concepts","author":"Broadus AE","year":"1994"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.3.E489"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13030"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11706"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.10016"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90487-5"},{"key":"e_1_2_7_16_1","first-page":"269","volume-title":"Pediatric diseases related to calcium","author":"Frame B","year":"1980"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00409-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00218-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng844"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.11.4149-4158.2000"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.1.160"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.11.6882"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07686.x"},{"key":"e_1_2_7_24_1","first-page":"253","article-title":"\u00dcber atypische Chondrodystrophie (Achondroplasie) und \u00fcber eine noch nicht beschriebene angeborene Wachstumsst\u00f6rung des Knochensystems: Metaphys\u00e4re Dysostosis","volume":"61","author":"Jansen M","year":"1934","journal-title":"Zeitschr Orthop Chir"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2918"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006564200"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1658941"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00060793-199712000-00009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.139.12.5255"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.3.277"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1242\/dev.127.3.543","article-title":"Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related\u2010protein\u2010dependent and\u2010independent pathways","volume":"127","author":"Karp SJ","year":"2000","journal-title":"Development"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1210\/jcem.84.10.6033","article-title":"A frame\u2010shift mutation in the type I parathyroid hormone (PTH)\/PTH\u2010related peptide receptor causing Blomstrand lethal osteochondrodysplasia","volume":"84","author":"Karperien M","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_7_33_1","first-page":"283","article-title":"Functional analysis of the PTH\/PTHrP network of ligands and receptors","volume":"53","author":"Kronenberg H","year":"1998","journal-title":"Recent Prog Horm Res"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01657"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77991-6_15"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957529"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.663"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.12.6361"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.134.1.441"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.2.7835276"},{"key":"e_1_2_7_41_1","first-page":"F186","article-title":"Localization of parathyroid hormone\/parathyroid hormone\u2010related peptide receptor mRNA in kidney","volume":"270","author":"Lee K","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1658940"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1242\/dev.128.4.541","article-title":"The CREB family of activators is required for endochondral bone development","volume":"128","author":"Long F","year":"2001","journal-title":"Development"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.24.5099"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214817"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.22.4523"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00261-7"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008195"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.990702"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.10.3584"},{"key":"e_1_2_7_51_1","first-page":"1173","volume-title":"Vitamin D, basic research and its clinical application","author":"Rao DS","year":"1979"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.132.5.2157"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7701349"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609053351004"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13689"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.9.3052"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.10012"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.16.2072"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00798-3"},{"key":"e_1_2_7_60_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1210\/endo.133.2.8393771","article-title":"Parathyroid hormone (PTH)\/PTH\u2010related peptide (PTHrP) receptor mRNA are widely distributed in rat tissues","volume":"133","author":"Urena P","year":"1993","journal-title":"Endocrinology"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.1.23"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.613"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10240"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.3.441"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.7.1285"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.4.1788"},{"key":"e_1_2_7_67_1","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1242\/dev.121.11.3539","article-title":"Overexpression of parathyroid hormone\u2010related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development","volume":"121","author":"Wysolmerski JJ","year":"1995","journal-title":"Development"},{"key":"e_1_2_7_68_1","first-page":"S647","volume-title":"Jansen\u2010type metaphyseal chondrodysplasia: examination of the PTH\/PTHrP receptor by the RT\u2010PCR","author":"Yasuda Y","year":"1996"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.9.5245"}],"container-title":["Birth Defects Research Part C: Embryo Today: Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrc.10028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrc.10028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T22:35:53Z","timestamp":1700174153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrc.10028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1002\/bdrc.10028"],"URL":"https:\/\/doi.org\/10.1002\/bdrc.10028","archive":["Portico"],"relation":{},"ISSN":["1542-975X","1542-9768"],"issn-type":[{"value":"1542-975X","type":"print"},{"value":"1542-9768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}