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The majority of the body's P\n                    <jats:sub>i<\/jats:sub>\n                    exists in the mineralized matrix of bones and teeth. Systemic P\n                    <jats:sub>i<\/jats:sub>\n                    metabolism is regulated by a cast of hormones, phosphatonins, and other factors via the bone\u2010kidney\u2010intestine axis. Mineralization in bones and teeth is in turn affected by homeostasis of P\n                    <jats:sub>i<\/jats:sub>\n                    and inorganic pyrophosphate (PPi), with further regulation of the P\n                    <jats:sub>i<\/jats:sub>\n                    \/PP\n                    <jats:sub>i<\/jats:sub>\n                    ratio by cellular enzymes and transporters. Much has been learned by analyzing the molecular basis for changes in mineralized tissue development in mutant and knock\u2010out mice with altered P\n                    <jats:sub>i<\/jats:sub>\n                    metabolism. This review focuses on factors regulating systemic and local P\n                    <jats:sub>i<\/jats:sub>\n                    homeostasis and their known and putative effects on the hard tissues of the oral cavity. By understanding the role of P\n                    <jats:sub>i<\/jats:sub>\n                    metabolism in the development and maintenance of the oral mineralized tissues, it will be possible to develop improved regenerative approaches. Birth Defects Research (Part C) 84:281\u2013314, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/bdrc.20136","type":"journal-article","created":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T20:17:29Z","timestamp":1228853849000},"page":"281-314","source":"Crossref","is-referenced-by-count":69,"title":["Phosphate: Known and potential roles during development and regeneration of teeth and supporting structures"],"prefix":"10.1002","volume":"84","author":[{"given":"Brian L.","family":"Foster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Tompkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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