{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:26:49Z","timestamp":1778635609602,"version":"3.51.4"},"reference-count":144,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T00:00:00Z","timestamp":1268870400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt C"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heparan sulfate (HS) is a structurally complex polysaccharide located on the cell surface and in the extracellular matrix, where it participates in numerous biological processes through interactions with a vast number of regulatory proteins such as growth factors and morphogens. HS is crucial for lung development; disruption of HS synthesis in flies and mice results in a major aberration of airway branching, and in mice, it results in neonatal death as a consequence of malformed lungs and respiratory distress. Epithelial\u2013mesenchymal interactions governing lung morphogenesis are directed by various diffusible proteins, many of which bind to, and are regulated by HS, including fibroblast growth factors, sonic hedgehog, and bone morphogenetic proteins. The majority of research into the molecular mechanisms underlying defective lung morphogenesis and pulmonary pathologies, such as bronchopulmonary dysplasia and pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH), has focused on abnormal protein expression. The potential contribution of HS to abnormalities of lung development has yet to be explored to any significant extent, which is somewhat surprising given the abnormal lung phenotype exhibited by mutant mice synthesizing abnormal HS. This review summarizes our current understanding of the role of HS and HS\u2010binding proteins in lung morphogenesis and will present in vitro and in vivo evidence for the fundamental importance of HS in airway development. Finally, we will discuss the future possibility of HS\u2010based therapeutics for ameliorating insufficient lung growth associated with lung diseases such as CDH. Birth Defects Research (Part C) 90:32\u201344, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrc.20169","type":"journal-article","created":{"date-parts":[[2010,3,20]],"date-time":"2010-03-20T22:48:48Z","timestamp":1269125328000},"page":"32-44","source":"Crossref","is-referenced-by-count":18,"title":["Heparan sulfate in lung morphogenesis: The elephant in the room"],"prefix":"10.1002","volume":"90","author":[{"given":"Sophie M.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin C.","family":"Jesudason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy E.","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Fernig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,18]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22032"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.1.L250"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2797"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511902200"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401500202"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200106075"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307053"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2423"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.1.53"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.23.4867"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.6.1693"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81270-2"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00508-1"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.8.4350"},{"key":"e_1_2_17_16_1","first-page":"L495","article-title":"Differential effect of platelet\u2010derived growth factor on glycosaminoglycan synthesis by fetal rat lung cells","volume":"263","author":"Caniggia I","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1991.261.6.L424"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199703)208:3<398::AID-AJA10>3.0.CO;2-X"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02310"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.11.2095"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200205-468OC"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.4.961"},{"key":"e_1_2_17_23_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal\u2010epithelial signaling during mouse organogenesis","volume":"127","author":"De Moerlooze L","year":"2000","journal-title":"Development"},{"issue":"12","key":"e_1_2_17_24_1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1242\/jcs.112.12.1999","article-title":"Differential regulation of hepatocyte growth factor\/scatter factor by cell surface proteoglycans and free glycosaminoglycan chains","volume":"112","author":"Deakin JA","year":"1999","journal-title":"J Cell Sci"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.01.020"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568014023355935"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.293.5535.1663"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01111-X"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0079OC"},{"key":"e_1_2_17_30_1","first-page":"106","article-title":"The transition from fetal to neonatal circulation: normal responses and implications for infants with heart disease","volume":"17","author":"Friedman AH","year":"1993","journal-title":"Semin Perinatol"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<159::AID-DVDY3>3.0.CO;2-9"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-355"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01935"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.2.165"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607434200"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070260506"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199204000-00004"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.1.209"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199607)206:3<318::AID-AJA9>3.0.CO;2-L"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20355"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00114-3"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00081.2003"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.1.51"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588402320439685"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050738"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.6919"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0304OC"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00498.2005"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0445"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-415"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.068544"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011354200"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32250-0"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68615-7"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2207"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.9.1668"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111826200"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02427.x"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00124-0"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.16.4.9115748"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010291200"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-007-9080-5"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300219200"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.17.3715"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9798"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.41.26265"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.20.3943"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2790821"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01189076"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4850"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/01902140490476454"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.4.L667"},{"key":"e_1_2_17_73_1","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.1016\/S0021-9258(19)78112-5","article-title":"Liver heparan sulfate structure. A novel molecular design","volume":"269","author":"Lyon M","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2420493"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.17804"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwh067"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.668"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07005"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.20.3156"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21398"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205131200"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401774200"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007057826179"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.4.1015"},{"key":"e_1_2_17_85_1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1242\/dev.125.7.1315","article-title":"Hepatocyte growth factor (HGF) acts as a mesenchyme\u2010derived morphogenic factor during fetal lung development","volume":"125","author":"Ohmichi H","year":"1998","journal-title":"Development"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.2741\/3007"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21038"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02679"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8994"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.22.4.3854"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709995200"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113701"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110.2.609"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70446-4"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06631.x"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.114.1.233"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.10.3107"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.4.2994"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.13.7303"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi972468t"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000359200"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199812000-00003"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.1177\/41.6.7686196"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.51.36267"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2520576.x"},{"key":"e_1_2_17_106_1","doi-asserted-by":"crossref","first-page":"13100","DOI":"10.1016\/S0021-9258(17)36804-7","article-title":"Fine structure of heparan sulfate regulates syndecan\u20101 function and cell behavior","volume":"269","author":"Sanderson RD","year":"1994","journal-title":"JBiol Chem"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.1997.tb00077.x"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.23.1.3926"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.6.1759"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/5096"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000237200"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.8.2153"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1340"},{"key":"e_1_2_17_114_1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1242\/dev.126.8.1675","article-title":"Induction of alveolar type II cell differentiation in embryonic tracheal epithelium in mesenchyme\u2010free culture","volume":"126","author":"Shannon JM","year":"1999","journal-title":"Development"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<482::AID-AJA2>3.0.CO;2-D"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.5.L1030"},{"key":"e_1_2_17_117_1","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1242\/dev.121.8.2559","article-title":"PDGF\u2010AA and its receptor influence early lung branching via an epithelial\u2010mesenchymal interaction","volume":"121","author":"Souza P","year":"1995","journal-title":"Development"},{"key":"e_1_2_17_118_1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1242\/dev.120.8.2163","article-title":"Antisense oligodeoxynucleotides targeting PDGF\u2010B mRNA inhibit cell proliferation during embryonic rat lung development","volume":"120","author":"Souza P","year":"1994","journal-title":"Development"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81803-6"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90061-9"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199612)207:4<439::AID-AJA8>3.0.CO;2-I"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1864-8"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.009712"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2269"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2650715"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2730553"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2770297"},{"key":"e_1_2_17_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502065200"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6499"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/453733a"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00325-1"},{"key":"e_1_2_17_132_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.supplement_2.2106064"},{"key":"e_1_2_17_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00117-9"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.12.2695"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.18.3615"},{"key":"e_1_2_17_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401750405"},{"key":"e_1_2_17_137_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.004879"},{"key":"e_1_2_17_138_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02313"},{"key":"e_1_2_17_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.04.042"},{"key":"e_1_2_17_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1140"},{"key":"e_1_2_17_141_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.2.4096"},{"key":"e_1_2_17_142_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0298"},{"key":"e_1_2_17_143_1","first-page":"L419","article-title":"Expression of transforming growth factor\u2010beta type II receptor in rat lung is regulated during development","volume":"269","author":"Zhao Y","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_17_144_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.6.L1231"},{"key":"e_1_2_17_145_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0110"}],"container-title":["Birth Defects Research Part C: Embryo Today: Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrc.20169","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrc.20169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:20:14Z","timestamp":1696641614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrc.20169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":144,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/bdrc.20169"],"URL":"https:\/\/doi.org\/10.1002\/bdrc.20169","archive":["Portico"],"relation":{},"ISSN":["1542-975X","1542-9768"],"issn-type":[{"value":"1542-975X","type":"print"},{"value":"1542-9768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}