{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:44:19Z","timestamp":1791236659275,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T00:00:00Z","timestamp":1276214400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt C"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several teratogenic agents, including ionizing radiation and xenobiotics such as phenytoin, benzo[a]pyrene, thalidomide, and methamphetamine, can initiate the formation of reactive oxygen species (ROS) that oxidatively damage cellular macromolecules including DNA. Oxidative DNA damage, and particularly the most prevalent 8\u2010oxoguanine lesion, may adversely affect development, likely via alterations in gene transcription rather than via a mutational mechanism. Contributions from oxidative DNA damage do not exclude roles for alternative mechanisms of initiation like receptor\u2010mediated processes or the formation of covalent xenobiotic\u2013macromolecular adducts, damage to other macromolecular targets like proteins and lipids, and other effects of ROS like altered signal transduction. Even in the absence of teratogen exposure, endogenous developmental oxidative stress can have embryopathic consequences in the absence of key pathways for detoxifying ROS or repairing DNA damage. Critical proteins in pathways for DNA damage detection\/repair signaling, like p53 and ataxia telangiectasia mutated, and DNA repair itself, like oxoguanine glycosylase 1 and Cockayne syndrome B, can often, but not always, protect the embryo from ROS\u2010initiating teratogens. Protection may be variably dependent upon such factors as the nature of the teratogen and its concentration within the embryo, the stage of development, the species, strain, gender, target tissue and cell type, among other factors. Birth Defects Research (Part C) 90:103\u2013109, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrc.20177","type":"journal-article","created":{"date-parts":[[2010,6,12]],"date-time":"2010-06-12T06:19:05Z","timestamp":1276323545000},"page":"103-109","source":"Crossref","is-referenced-by-count":99,"title":["Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits"],"prefix":"10.1002","volume":"90","author":[{"given":"Peter G.","family":"Wells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon P.","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla C. H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Ondovcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.017855"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.03.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0903fje"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1242\/dev.125.16.3225","article-title":"The role of p53 and cell death by apoptosis and necrosis in 4\u2010hydroperoxycyclophosphamide\u2010induced limb malformations","volume":"125","author":"Moallem SA","year":"1998","journal-title":"Development"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0695-181"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.1.111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/8466"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","unstructured":"PrestonTJ HendersonJT McCallumGP WellsPG.2007.Cellular models of altered base excision repair reveal a differential contribution of reactive oxygen species\u2010induced 7 8\u2010dihydro\u20108\u2010oxo\u20102\u2032\u2010deoxyguanosine to the cytotoxic mechanisms of platinum anticancer drugs cisplatin and oxaliplatin. Paper presented at: Proceedings of the FASEB Experimental Biology Meeting Washington DC Abstract No. 765.","DOI":"10.1096\/fasebj.21.6.A1191-a"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0929"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(97)00175-9"},{"key":"e_1_2_7_15_1","series-title":"Handbook of experimental pharmacology","first-page":"131","volume-title":"Mechanisms of adverse drug reactions","author":"Wells PG","year":"2009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn263"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.052639"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00340-1"},{"key":"e_1_2_7_19_1","volume-title":"The role of oxidative DNA damage and repair in methamphetamine\u2010initiated neurodevelopmental deficits","author":"Wong AW","year":"2006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2557-08.2008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00422-0"}],"container-title":["Birth Defects Research Part C: Embryo Today: Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrc.20177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrc.20177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:52:06Z","timestamp":1697514726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrc.20177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/bdrc.20177"],"URL":"https:\/\/doi.org\/10.1002\/bdrc.20177","archive":["Portico"],"relation":{},"ISSN":["1542-975X","1542-9768"],"issn-type":[{"value":"1542-975X","type":"print"},{"value":"1542-9768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}