{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:52:02Z","timestamp":1765381922161,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","award":["22358"],"award-info":[{"award-number":["22358"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt C"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>In this review article I explore the suitability of human epidermal neural crest stem cells (hEPI\u2010NCSC) for translational medicine. hEPI\u2010NCSC are multipotent somatic stem cells that are derived from the embryonic neural crest. hEPI\u2010NCSC are located in the bulge of hair follicles where they persist postnatally and into adulthood. Because of their location in the hairy skin and their migratory behavior, hEPI\u2010NCSC can be easily isolated as a highly pure population of stem cells without the need for purification. Furthermore they can be expanded ex vivo into millions of stem cells, they do not form tumors in vivo, and they can undergo directed differentiation into crest and noncrest\u2010derived cell types of clinical relevance. Taken together, these characteristics make hEPI\u2010NCSC attractive candidates for cell\u2010based therapies, drug discovery, and disease modeling. Birth Defects Research (Part C) 102:221\u2013226, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdrc.21073","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T17:00:22Z","timestamp":1410886822000},"page":"221-226","source":"Crossref","is-referenced-by-count":16,"title":["Human epidermal neural crest stem cells as candidates for cell\u2010based therapies, disease modeling, and drug discovery"],"prefix":"10.1002","volume":"102","author":[{"given":"Maya","family":"Sieber\u2010Blum","sequence":"first","affiliation":[{"name":"Institute of Genetic Medicine, Centre for Life Newcastle University Newcastle upon Tyne NE1 3BZ United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.02.086"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-011-9255-5"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90303-K"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0129"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1069"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1154"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2004.07209008.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0233"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9152-3"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01429"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.15.7391"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.35"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.21.3179"},{"volume-title":"The developing human","year":"1982","author":"Moore KL","key":"e_1_2_3_15_1"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8913"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-013-9466-z"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-013-9493-9"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920070043"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1140"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90383-2"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.10.034"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15069314"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20008"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20129"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.02.003"},{"key":"e_1_2_3_27_1","first-page":"pii","article-title":"Mouse epidermal neural crest stem cell (EPI\u2010NCSC) cultures","volume":"15","author":"Sieber\u2010Blum M","year":"2008","journal-title":"J Vis Exp"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-008-9042-0"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-014-0323-4"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092436"}],"container-title":["Birth Defects Research Part C: Embryo Today: Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrc.21073","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrc.21073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T21:27:07Z","timestamp":1696627627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrc.21073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/bdrc.21073"],"URL":"https:\/\/doi.org\/10.1002\/bdrc.21073","archive":["Portico"],"relation":{},"ISSN":["1542-975X","1542-9768"],"issn-type":[{"type":"print","value":"1542-975X"},{"type":"electronic","value":"1542-9768"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}