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Single whole\u2010body exposure of animals to EHF EMR at the intensity of 0.1\u2009mW\/cm<jats:sup>2<\/jats:sup> for 20\u2009min at 1\u2009h after zymosan injection reduced both the footpad edema and local hyperthermia on average by 20% at the frequencies of 42.2, 51.8, and 65\u2009GHz. Some other frequencies from the frequency range of 37.5\u201370\u2009GHz were less effective or not effective at all. At fixed frequency of 42.2\u2009GHz and intensity of 0.1\u2009mW\/cm<jats:sup>2<\/jats:sup>, the effect had bell\u2010shaped dependence on exposure duration with a maximum at 20\u201340\u2009min. Reduction of intensity to 0.01\u2009mW\/cm<jats:sup>2<\/jats:sup> resulted in a change of the effect dependence on exposure duration to a linear one. Combined action of cyclooxygenase inhibitor sodium diclofenac and EHF EMR exposure caused a partial additive effect of decrease in footpad edema. Combined action of antihistamine clemastine and EHF EMR exposure caused a dose\u2010dependent abolishment of the anti\u2010inflammatory effect of EHF EMR. The results obtained suggest that arachidonic acid metabolites and histamine are involved in realization of anti\u2010inflammatory effects of low\u2010intensity EHF EMR. Bioelectromagnetics 29:197\u2013206, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bem.20381","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T23:18:49Z","timestamp":1196291929000},"page":"197-206","source":"Crossref","is-referenced-by-count":40,"title":["Anti\u2010inflammatory effects of low\u2010intensity extremely high\u2010frequency electromagnetic radiation: Frequency and power dependence"],"prefix":"10.1002","volume":"29","author":[{"given":"A.B.","family":"Gapeyev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.N.","family":"Mikhailik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.K.","family":"Chemeris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"18","volume-title":"Manual on experimental (pre\u2010clinical) study of the new pharmacological substances","author":"Arzamastsev EV","year":"2000"},{"key":"e_1_2_1_3_1","first-page":"101","article-title":"Antiallergic anti\u2010inflammatory effects of H1\u2010antihistamines in humans","volume":"17","author":"Assanasen P","year":"2002","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.60.5.1133"},{"key":"e_1_2_1_5_1","first-page":"13","article-title":"Non\u2010thermal biological effects of microwaves","volume":"11","author":"Belyaev IY","year":"2005","journal-title":"Microwave Rev"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v28.i12.420"},{"issue":"38","key":"e_1_2_1_7_1","first-page":"23","article-title":"Application of low\u2010intensity millimeter waves in medicine (retrospective review)","volume":"2","author":"Betskii OV","year":"2005","journal-title":"Millimeter Waves Biol Med"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01301.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00717743"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236105"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb02385.x"},{"key":"e_1_2_1_12_1","volume-title":"\u201cProtein\u2010Machine\u201d. 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