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The murine nose area was exposed to MMW of \u201ctherapeutic\u201d frequencies: 42.25, 53.57, and 61.22\u2009GHz. MMWT\u2010induced hypoalgesia was shown to be frequency dependent in two experimental models: (1) the cold water tail\u2010flick test (chronic non\u2010neuropathic pain), and (2) the wire surface test (chronic neuropathic pain following unilateral constriction injury to the sciatic nerve). Maximum hypoalgesic effect was obtained when the frequency was 61.22\u2009GHz. Other exposure parameters were: incident power density\u2009=\u200913.3\u2009mW\/cm<jats:sup>2<\/jats:sup>, duration of each exposure\u2009=\u200915\u2009min. Involvement of \u03b4 and \u03ba endogenous opioids in the MMWT\u2010induced hypoalgesia was demonstrated using selective blockers of \u03b4\u2010 and \u03ba\u2010opioid receptors and the direct ELISA measurement of endogenous opioids in CNS tissue. Possible mechanisms of the effect and the perspectives of the clinical application of MMWT are discussed. 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