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In a previous article, we showed that fluid phase endocytosis rate increases when cultured cells are exposed to 900 MHz EMF similar to mobile phones' modulated GSM signals (217 Hz repetition frequency, 576 \u00b5s pulse width) and to electric pulses similar to the GSM electrical component. Trying to distinguish the mechanisms sustaining this endocytosis stimulation, we exposed murine melanoma cells to Lucifer Yellow (LY) or to GSM\u2013EMF\/electric pulses in the presence of drugs inhibiting the clathrin\u2010 or the caveolin\u2010dependent endocytosis. Experiments were performed at a specific absorption rate (SAR) of 3.2 W\/kg in a wire patch cell under homogeneously distributed EMF field and controlled temperature (in the range of 28.5\u201329.5 \u00b0C). Thus, the observed increase in LY uptake was not a thermal effect. Chlorpromazine and ethanol, but not Filipin, inhibited this increase. Therefore, the clathrin\u2010dependent endocytosis is stimulated by the GSM\u2013EMF, suggesting that the cellular mechanism affected by the modulated EMF involves vesicles that detach from the cell membrane, mainly clathrin\u2010coated vesicles. Bioelectromagnetics 30:222\u2013230, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bem.20463","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T14:30:23Z","timestamp":1229092223000},"page":"222-230","source":"Crossref","is-referenced-by-count":16,"title":["900 MHz modulated electromagnetic fields accelerate the clathrin\u2010mediated endocytosis pathway"],"prefix":"10.1002","volume":"30","author":[{"given":"Mihaela 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