{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:32:08Z","timestamp":1772022728305,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,8,10]],"date-time":"2009-08-10T00:00:00Z","timestamp":1249862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulsed electromagnetic fields (PEMF) have been used widely to treat nonunion fractures and related problems in bone healing, as a biological and physical method. With the use of Helmholtz coils and PEMF stimulators to generate uniform time\u2010varying electromagnetic fields, the effects of extremely low frequency electromagnetic fields on bone mineral density (BMD) and local factor production in disuse osteoporosis (DOP) rats were investigated. Eighty 4\u2010month\u2010old female Sprague Dawley (SD) rats were randomly divided into intact (INT) group, DOP group, calcitonin\u2010treated (CT) group, and PEMF stimulation group. The right hindlimbs of all the rats were immobilized by tibia\u2010tail fixation except for those rats in the INT group. Rats in the CT group were injected with calcitonin (2\u2009IU\/kg, i.p., once a day) and rats in the PEMF group were irradiated with PEMF immediately postoperative. The BMD, serum transforming growth factor\u2010beta 1 (TGF\u2010\u03b21), and interleukin\u20106 (IL\u20106) concentration of the proximal femur were measured 1, 2, 4, and 8 weeks after treatment. Compared with the CT and DOP groups, the BMD and serum TGF\u2010\u03b21 concentration in the PEMF group increased significantly after 8 weeks. The IL\u20106 concentration in the DOP group was elevated significantly after operation. The PEMF group showed significantly lower IL\u20106 level than the DOP group. The results found demonstrate that PEMF stimulation can efficiently suppress bone mass loss. We, therefore, conclude that PEMF may affect bone remodeling process through promoting TGF\u2010\u03b21 secretion and inhibiting IL\u20106 expression. Bioelectromagnetics 31:113\u2013119, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bem.20535","type":"journal-article","created":{"date-parts":[[2009,8,10]],"date-time":"2009-08-10T14:34:17Z","timestamp":1249914857000},"page":"113-119","source":"Crossref","is-referenced-by-count":78,"title":["Pulsed electromagnetic fields stimulation affects BMD and local factor production of rats with disuse osteoporosis"],"prefix":"10.1002","volume":"31","author":[{"given":"Wei\u2010Wei","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,10]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"451","article-title":"Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMFs)","volume":"17","author":"Bassett CA","year":"1989","journal-title":"Crit Rev Biomed Eng"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.6.1999"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.10078"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.20016"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0490-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-6002"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117990"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1143\/JPSJ.12.1158"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00383-O"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.3.702"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2000.00645.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504179200"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2003.10.005"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040307"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005860100269"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200109000-00012"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10669-007-9128-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00495.2005"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-006-9006-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00969.2001"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990152673828"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0600-3"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(01)00138-5"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00228-8"},{"key":"e_1_2_1_26_1","first-page":"2004","article-title":"Effects of low intensity PEMFs on bone mineral density and histomorphometry in SD rats","volume":"25","author":"Xu QL","year":"2004","journal-title":"J Fourth Mil Med Univ"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1541\/ieejfms.127.505"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B5.9150"}],"container-title":["Bioelectromagnetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbem.20535","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.20535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:44:48Z","timestamp":1700588688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bem.20535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/bem.20535"],"URL":"https:\/\/doi.org\/10.1002\/bem.20535","archive":["Portico"],"relation":{},"ISSN":["0197-8462","1521-186X"],"issn-type":[{"value":"0197-8462","type":"print"},{"value":"1521-186X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,10]]}}}