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RF exposure for 24\u2009h at a specific absorption rate (SAR) of 10\u2009W\/kg was carried out in a waveguide system under accurately controlled environmental and dosimetric parameters. DNA integrity, cell viability, and apoptosis were investigated as cellular endpoints relevant for carcinogenesis and other diseases of the central nervous system. Very sensitive biological assays were employed to assess the effects immediately after RF exposure and 24\u2009h later, as demonstrated by the cellular response elicited in PC12 cells using positive control treatments provided for each assay. In our experimental conditions, 24\u2009h of RF exposure at a carrier frequency and modulation scheme typical of a UMTS signal was not able to elicit any effect in the selected cellular endpoints in undifferentiated PC12 cells, despite the application of a higher SAR value than those applied in the majority of the studies reported in the literature. Bioelectromagnetics  33:497\u2013507, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bem.21712","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T02:15:59Z","timestamp":1329876959000},"page":"497-507","source":"Crossref","is-referenced-by-count":26,"title":["Radiofrequency radiation at 1950\u2009MHz (UMTS) does not affect key cellular endpoints in neuron\u2010like PC12 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