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The mechanism of these effects is assumed to be a stress response induced by ELF\u2010MF exposure. However, this mechanism remains controversial. In the present study, we investigated whether chronic ELF\u2010MF exposure (intensity, 3\u2009mT; total exposure, 200\u2009h) affected emotional behavior and corticosterone synthesis in mice. ELF\u2010MF\u2010treated mice showed a significant increase in total immobility time in a forced swim test and showed latency to enter the light box in a light\u2013dark transition test, compared with sham\u2010treated (control) mice. Corticosterone secretion was significantly high in the ELF\u2010MF\u2010exposed mice; however, no changes were observed in the amount of the adrenocorticotropic hormone and the expression of genes related to stress response. Quantification of the mRNA levels of adrenal corticosteroid synthesis enzymes revealed a significant reduction in <jats:italic>Cyp17a1<\/jats:italic> mRNA in the ELF\u2010MF\u2010exposed mice. Our findings suggest the possibility that high intensity and chronic exposure to ELF\u2010MF induces an increase in corticosterone secretion, along with depression\u2010 and\/or anxiety\u2010like behavior, without enhancement of the hypothalamic\u2013pituitary\u2013adrenal axis. Bioelectromagnetics  34:43\u201351, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bem.21743","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T14:16:48Z","timestamp":1341238608000},"page":"43-51","source":"Crossref","is-referenced-by-count":39,"title":["Chronic exposure to an extremely low\u2010frequency magnetic field induces depression\u2010like behavior and corticosterone secretion without enhancement of the hypothalamic\u2013pituitary\u2013adrenal axis in 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