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Femurs were exposed to 20, 40, 60, or 80\u2009W of microwave radiation for 30\u2009min (microwave applicator at 2450\u2009MHz), and temperatures of the implants and muscles adjacent to implants were recorded. To evaluate thermal damage, nerves were electrodiagnostically assessed immediately after radiation, and histologic studies performed on nerve and muscle sections. As expected, implant temperature was highest in the exposure field. Temperatures of limbs with titanium alloy implants increased significantly at 60 and 80\u2009W, with a significant decline in the nerve conduction velocity and acute thermal injuries in nerves and muscles adjacent to implants. However, temperature remained unchanged and no adverse effects were observed in nerves and muscles at 20 and 40\u2009W. These findings are inconsistent with the current notion that surgical metal implants in the treatment field are contraindications for microwave therapy. Hence, we believe that a lower dose of continuous wave microwave irradiation is safe for limbs with titanium alloy implants. 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