{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:08:27Z","timestamp":1790161707781,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kahramanmaras Sutcu Imam University Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Cell\u2010based or magnetic field therapies as alternative approaches to pain management have been tested in several experimental pain models. The aim of this study therefore was to investigate the actions of the cell\u2010based therapy (adipose tissue derived mesenchymal stem cells; ADMSC) or pulsed magnetic field (PMF) therapy and magneto\u2010cell therapy (combination of ADMSC and PMF) in chronic constriction nerve injury model (CCI). The actions of individual ADMSC (route dependent [systemic or local], time\u2010dependent [a day or a week after surgery]), or PMF and their combination (magneto\u2010cell) therapies on hyperalgesia and allodynia were investigated by using thermal plantar test and a dynamic plantar aesthesiometer, respectively. In addition, various cytokine levels (IL\u20101\u03b2, IL\u20106, and IL\u201010) of rat sciatic nerve after CCI were analyzed. Following the CCI, both latency and threshold significantly decreased. ADMSC or PMF significantly increased latencies and thresholds. The combination of ADMSC with PMF even more significantly increased latency and threshold when compared with ADMSC alone. However, ADMSC\u2010induced decrease in pro\u2010inflammatory or increase in anti\u2010inflammatory cytokines levels were partially prevented by PMF treatments. Present findings may suggest that both cell\u2010based and magnetic therapies can effectively attenuate chronic neuropathic pain symptoms. Combined magneto\u2010cell therapy may also efficiently reverse neuropathic signs. Bioelectromagnetics. 38:255\u2013264, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bem.22038","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T06:23:01Z","timestamp":1485584581000},"page":"255-264","source":"Crossref","is-referenced-by-count":32,"title":["Pulsed magnetic field enhances therapeutic efficiency of mesenchymal stem cells in chronic neuropathic pain model"],"prefix":"10.1002","volume":"38","author":[{"given":"Tufan","family":"Mert","sequence":"first","affiliation":[{"name":"Department of Biophysics School of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akif Hakan","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130diris","family":"Altun","sequence":"additional","affiliation":[{"name":"Department of Brain and Nerve Surgery Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furkan","family":"Baran","sequence":"additional","affiliation":[{"name":"School of Medicine (Medical Student) Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Gunay","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Medicine Cukurova University Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.08.013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20886"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.01.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00490-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem129"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.07.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9456-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15368370701580806"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.10.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080100"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.20524"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0101-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2015.1031408"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.11.004"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.014"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9428-2"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1992"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.11.004"},{"key":"e_1_2_5_23_1","first-page":"9","article-title":"Therapeutic uses of pulsed magnetic\u2010field exposure: A review","volume":"307","author":"Shupak NM","year":"2003","journal-title":"Rad Sci Bull"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130230"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1200138"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01069.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.12.007"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.54.132"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1533-2500.2003.00002.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000275190.42912.37"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.04.001"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0b013e318034194e"}],"container-title":["Bioelectromagnetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbem.22038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.22038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bem.22038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.22038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:04:45Z","timestamp":1693965885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bem.22038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,28]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/bem.22038"],"URL":"https:\/\/doi.org\/10.1002\/bem.22038","archive":["Portico"],"relation":{},"ISSN":["0197-8462","1521-186X"],"issn-type":[{"value":"0197-8462","type":"print"},{"value":"1521-186X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,28]]}}}