{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:19:40Z","timestamp":1791667180503,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11772226"],"award-info":[{"award-number":["11772226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572154"],"award-info":[{"award-number":["81572154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871777"],"award-info":[{"award-number":["81871777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Postmenopausal osteoporosis is a type of chronic disease with high morbidity and high economic burden. Due to the adverse effects of long\u2010term drug therapy, physical therapy, such as pulsed electromagnetic fields (PEMF), is widely implemented in clinical practice. Therefore, we first conducted the meta\u2010analysis on the efficacy and safety of PEMF in the treatment of postmenopausal osteoporosis. We searched eight databases to acquire potentially eligible studies. Outcome indicators include bone mineral density (BMD), visual analogue scale (VAS), biochemical markers of alkaline phosphatase (ALP), osteocalcin, bone\u2010specific alkaline phosphatase (BSAP), type I collagen carboxy\u2010terminal peptide (CTX), and adverse events. The results showed that a total of 19 studies (1303 patients) were retrieved from eight databases. Compared with conventional medications, PEMF combined with conventional medications significantly increased BMD of lumbar vertebra, femoral, Ward's triangle, bone\u2010specific biochemical indicators of ALP, BSAP, and osteocalcin, and relieved pain. However, The incidence of adverse events was not statistically significant between PEMF combined with conventional medications and conventional medications alone. Compared with conventional medications, PEMF significantly increased the BMD of the femur and reduced the degree of pain, but there was no statistical difference in the BMD of the lumbar spine between PEMF and placebo. Except osteocalcin, BSAP, CTX, and ALP showed no significant difference. In view of its efficacy and safety, PEMF intervention can be considered as a potentially effective complementary therapy for postmenopausal women with osteoporosis. \u00a9 2022 Bioelectromagnetics Society.<\/jats:p>","DOI":"10.1002\/bem.22419","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T05:00:57Z","timestamp":1658466057000},"page":"381-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pulse Electromagnetic Field for Treating Postmenopausal Osteoporosis: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-2821","authenticated-orcid":false,"given":"Shuang","family":"Lang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Orthopedic Research Institute Tianjin Hospital Tianjin China"},{"name":"Orthopaedics Institute Tianjin Hospital Tianjin China"},{"name":"Graduate School Tianjin University of Traditional Chinese Medicine Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Ma","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Orthopedic Research Institute Tianjin Hospital Tianjin China"},{"name":"Orthopaedics Institute Tianjin Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Gong","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Orthopedic Research Institute Tianjin Hospital Tianjin China"},{"name":"Orthopaedics Institute Tianjin Hospital Tianjin China"},{"name":"Graduate School Tianjin University of Traditional Chinese Medicine Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Orthopedic Research Institute Tianjin Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benchao","family":"Dong","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Orthopedic Research Institute Tianjin Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Orthopedic Research Institute Tianjin Hospital Tianjin China"},{"name":"Orthopaedics Institute Tianjin Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3681-2_16"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.20f13681"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92329-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05294-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4136.575"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.07.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2794-2"},{"key":"e_1_2_8_9_1","first-page":"ED000142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston M","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_10_1","first-page":"CD007950","article-title":"Effects and safety of periconceptional oral folate supplementation for preventing birth defects","volume":"12","author":"De\u2010Regil LM","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2017.1406914"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-020-00715-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2015.08.002"},{"key":"e_1_2_8_14_1","first-page":"157","article-title":"Comprehensive treatment of primary osteoporosis","volume":"10","author":"Fan HB","year":"2015","journal-title":"China Pract Med"},{"key":"e_1_2_8_15_1","first-page":"17","article-title":"Efficacy of combined treatment of postmenopausal osteoporosis","volume":"5","author":"Feng JW","year":"2015","journal-title":"China Med Pharm"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(01)80030-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20548"},{"key":"e_1_2_8_18_1","first-page":"1399","article-title":"Low\u2010frequency pulsed electromagnetic field combined with estrogen in the treatment of postmenopausal osteoporosis","volume":"7","author":"Huang S","year":"2003","journal-title":"Chin J\u00a0Clin Rehabil"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123743"},{"key":"e_1_2_8_20_1","first-page":"192","article-title":"Observation of the clinical efficacy of low\u2010frequency pulsed electromagnetic field in the treatment of postmenopausal osteoporosis","volume":"32","author":"Jiang JL","year":"2017","journal-title":"Chin J Rehabil Med"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2260"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4704-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1978"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000757"},{"key":"e_1_2_8_25_1","first-page":"1064","article-title":"Clinical observation of salmon calcitonin combine with low frequency PEMFs for the treatment of osteoporosis in postmenopausal women","volume":"19","author":"Liang LP","year":"2013","journal-title":"Chin J Osteopor"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.21770"},{"key":"e_1_2_8_27_1","first-page":"67","article-title":"Comparison between pulsed electromagnetic field and alendronate in the treatment of postmenopausal osteoporosis","volume":"29","author":"Liu Y","year":"2014","journal-title":"West Chin Med J"},{"key":"e_1_2_8_28_1","first-page":"154","article-title":"Effects of calcium carbonate, vitamin D3 and calcitonin combined with pulsed electromagnetic fields on osteoporosis in elderly women","volume":"15","author":"Ma LP","year":"2013","journal-title":"Mil Med J Southeast Chin"},{"key":"e_1_2_8_29_1","first-page":"97","article-title":"Bone pain mechanism in osteoporosis: A narrative review","volume":"13","author":"Mattia C","year":"2016","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3154-6"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13856"},{"key":"e_1_2_8_33_1","first-page":"945","article-title":"Clinical efficacy of zoledronic acid combined with pulsed electromagnetic field therapy on postmenopausal osteoporosis","volume":"21","author":"Qin Y","year":"2015","journal-title":"Chin J Osteopor"},{"key":"e_1_2_8_34_1","first-page":"431","article-title":"Observation on the efficacy of salmon calcitonin nasal spray combined with pulsed electromagnetic field therapy instrument in the treatment of osteoporotic low back pain","volume":"19","author":"Ru WY","year":"2014","journal-title":"Zhejiang J Traumat Surg"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2450327"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-186X(1997)18:3<193::AID-BEM1>3.0.CO;2-Y"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0847fje"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001831"},{"key":"e_1_2_8_39_1","first-page":"274","article-title":"The effect of low\u2010frequency pulsed electromagnetic field therapy on bone mineral density and bone metabolism indexes in elderly postmenopausal patients with osteoporosis","volume":"21","author":"Wang JM","year":"2019","journal-title":"J Chin Phys"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4158\/GL-2020-0524SUPPL"},{"key":"e_1_2_8_41_1","first-page":"34","article-title":"Clinical study of the effect of pulsed electromagnetic field on postmenopausal osteoporosis","volume":"23","author":"Xie ZL","year":"2009","journal-title":"Chin J Postgrad Med"},{"key":"e_1_2_8_42_1","first-page":"4","article-title":"Therapeutic effect of salmon calcitonin nasal spray combined with pulse electromagnetic therapeutic instrument in the treatment of osteoporotic lumbago","volume":"12","author":"Zhang B","year":"2014","journal-title":"J China Prescription Drug"},{"key":"e_1_2_8_43_1","first-page":"353","article-title":"Observation of therapeutic effect of pulsed electromagnetic field on postmenopausal osteoporosis","volume":"31","author":"Zhang XZ","year":"2009","journal-title":"Chin J Phys Med Rehabil"},{"key":"e_1_2_8_44_1","first-page":"664","article-title":"Clinical observation of rongjin tablets combined with low frequency pulsed electromagnetic field intervention in postmenopausal women with osteoporosis and bone pain and behavior ability","volume":"31","author":"Zhao XY","year":"2014","journal-title":"Tianjin J Tradit Chin Med"},{"key":"e_1_2_8_45_1","first-page":"247","article-title":"Effects of low frequency pulsed electromagnetic fields combined with alendronate on bone mineral density and bone metabolism in postmenopausal osteoporosis","volume":"8","author":"Zheng LQ","year":"2018","journal-title":"China Med Pharm"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.22065"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500675"}],"container-title":["Bioelectromagnetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.22419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bem.22419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.22419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T21:56:58Z","timestamp":1692741418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bem.22419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/bem.22419"],"URL":"https:\/\/doi.org\/10.1002\/bem.22419","archive":["Portico"],"relation":{},"ISSN":["0197-8462","1521-186X"],"issn-type":[{"value":"0197-8462","type":"print"},{"value":"1521-186X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2022-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}