{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:42:07Z","timestamp":1791160927283,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":8380,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While convulsions associated with fever represent a serious problem in pediatric medicine, conventional animal models of febrile convulsions suffer numerous technical limitations. A microwave\u2010hyperthermia model that eliminates these problems was tested. Microwave energy was used to increase the core temperature of 13\u2010 and 17\u2010day\u2010old rats, resulting in convulsions similar to febrile convulsions in human infants. Rats were irradiated for 10 min in circularly polarized waveguides at 918 MHz, CW (average SAR = 9.4 W\/kg at 13 days and 18.0 W\/kg at 17 days as determined by twin\u2010well calorimetry). Day 17 irradiated rats were less susceptible to convulsions than were day 13 irradiated rats, indicating an age\u2010dependent decline in susceptibility. Contrary to findings of earlier models using infrared or hot\u2010oven heating, convulsions induced with microwave hyperthermia impaired neither brain growth nor subsequent performance during behavioral testing. Simultaneous measurement of brain and rectal temperatures during microwave irradiation revealed differential heating rates that favor thermal homeostasis in brain tissue.<\/jats:p>","DOI":"10.1002\/bem.2250040406","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T15:59:42Z","timestamp":1181231982000},"page":"341-355","source":"Crossref","is-referenced-by-count":20,"title":["A microwave\u2010hyperthermia model of febrile convulsions"],"prefix":"10.1002","volume":"4","author":[{"given":"Dennis L.","family":"Hjeresen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M.","family":"Petracca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/401753"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1970.tb03880.x"},{"key":"e_1_2_1_4_1","volume-title":"Brain Dysfunction in Infantile Febrile Convulsions: International Brain Research Organization Monograph Series","author":"Aicardi J","year":"1976"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80666-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1029\/RS014i06Sp00187"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1152\/ajplegacy.1964.206.5.1057","article-title":"Evidence of injury by heat in mammalian tissue","volume":"206","author":"Burger FJ","year":"1964","journal-title":"Am J Physiol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1152\/ajplegacy.1964.206.5.1062","article-title":"Evidence of injury to tissues after hyperthermia","volume":"206","author":"Burger FJ","year":"1964","journal-title":"Am J Physiol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.2250010202"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240998"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.199.4324.90"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410100510"},{"key":"e_1_2_1_13_1","first-page":"241","volume-title":"Developmental Neurobiology","author":"Dobbing J","year":"1970"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.10.757"},{"key":"e_1_2_1_15_1","first-page":"565","volume-title":"Scientific Foundations of Pediatrics","author":"Dobbing J","year":"1974"},{"key":"e_1_2_1_16_1","volume-title":"Radiofrequency Radiation Dosimetry Handbook","author":"Durney CH","year":"1978"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500250021004"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80818-5"},{"key":"e_1_2_1_19_1","series-title":"NTIS document FDA 77\u20138011","first-page":"389","volume-title":"Biological Effects of Electromagnetic Waves","author":"Guy AW","year":"1975"},{"key":"e_1_2_1_20_1","unstructured":"GuyAW(1980): In: Non\u2010ionizing radiation Proceedings of a Topical Symposium ISBN: 0\u2013936712\u201330\u20109 pp.75\u2013101. (American Conference of Governmental Industrial Hygienists Cincinnati)."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196603102741007"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101907"},{"key":"e_1_2_1_23_1","first-page":"79","volume-title":"Handbook of Sensory Physiology. II: Somatosensory System","author":"Hensel H","year":"1973"},{"key":"e_1_2_1_24_1","series-title":"Proceedings of the 1978 Symposium on Electromagnetic Fields in Biological Systems Ottawa, Canada. June 28\u201330. 1978","first-page":"194","volume-title":"Shuttlebox side preference during pulsed microwave and conventional auditory cues","author":"Hjeresen DL","year":"1979"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7268407"},{"key":"e_1_2_1_26_1","series-title":"Symposium proceedings, Richmond, Virginia, Sept 17\u201319, 1969 (BRH\/DBE 70\u20132)","volume-title":"Biological Effects and Health Implications of Microwave Radiation","author":"Justesen DR","year":"1969"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(49)80054-0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(82)90092-4"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1982.tb05065.x"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(60)80188-6"},{"key":"e_1_2_1_31_1","volume-title":"Febrile Convulsions","author":"Millichap JG","year":"1968"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.3.246"},{"key":"e_1_2_1_33_1","first-page":"277","article-title":"Febrile seizures: Long\u2010term management of children with fever\u2010associated seizures","volume":"26","author":"NIH Consensus Statement","year":"1980","journal-title":"Br Med J"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0031-3955(16)33003-6","article-title":"The child who convulses with fever","volume":"21","author":"Oullette E","year":"1974","journal-title":"Ped Clin North Am"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb36025.x"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90526-9"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.98.4.574"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490250056006"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.142.3593.684"}],"container-title":["Bioelectromagnetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbem.2250040406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.2250040406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T06:26:32Z","timestamp":1697783192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bem.2250040406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/bem.2250040406"],"URL":"https:\/\/doi.org\/10.1002\/bem.2250040406","archive":["Portico"],"relation":{},"ISSN":["0197-8462","1521-186X"],"issn-type":[{"value":"0197-8462","type":"print"},{"value":"1521-186X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}