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This permeability effect is enhanced for relative hypoxia which is characteristic of intracellular oxygen tension (pO<jats:sub>2<\/jats:sub> \u2a7d 5 mm Hg). Neither the permeability nor the pO<jats:sub>2<\/jats:sub> effects are observed in temperature\u2010matched (\u00b1 0.05\u00b0C), sham\u2010exposed controls. In addition, at T<jats:sub>c<\/jats:sub>, microwave exposure is observed to induce the shedding or release of two erythrocyte proteins not seen in sham\u2010exposed controls. Moreover, the enhanced shedding of at least seven other proteins all of molecular weight \u2a7d 28,000 D was detected in the microwave\u2010treated samples. Using sensitive silver staining we estimate that approximately 450 fg of protein were shed per erythrocyte. These results demonstrate that temperature and pO<jats:sub>2<\/jats:sub> are important influences on both functional and structural responses of cell membranes to microwave radiation.<\/jats:p>","DOI":"10.1002\/bem.2250050215","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T00:24:24Z","timestamp":1139012664000},"page":"283-291","source":"Crossref","is-referenced-by-count":50,"title":["Microwave bioeffects in the erythrocyte are temperature and pO<sub>2<\/sub> dependent: Cation permeability and protein shedding occur at the membrane phase transition"],"prefix":"10.1002","volume":"5","author":[{"given":"R. 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