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A viremic stage occurs during the first 4 to 5 days after JEV administration in mice, and both microwave radiation (2.45\u2010GHz, continuous wave, 10\u2010min exposure) and hypercarbia were employed to increase CEC permeability to JEV. Exposure to microwaves at power densities of 10\u201350 mW\/cm<jats:sup>2<\/jats:sup> resulted in a dose\u2010dependent increase in JEV\u2010induced lethality. Mice did not become tolerant or sensitized to microwave potentiation of JEV\u2010induced mortality because 4 daily exposures at 10 or 50 mW\/cm<jats:sup>2<\/jats:sup> (SARS, \u223c 24\u201398 W\/kg) did not alter the lethality pattern to subsequent microwave radiation of JEV\u2010exposed animals. Similarly, hypercarbia (5, 10, and 20% CO<jats:sub>2<\/jats:sub>) was observed to produce a dose\u2010dependent increase in JEV\u2010induced lethality. Both microwave radiation and hypercarbia are thought to promote pinocytosis in CNS capillary endothelial cells. This may be one mechanism by which they enhance JEV\u2010induced lethality in adult Swiss\u2010Cox mice.<\/jats:p>","DOI":"10.1002\/bem.2250120603","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T08:20:10Z","timestamp":1139041210000},"page":"335-348","source":"Crossref","is-referenced-by-count":16,"title":["Japanese encephalitis virus (JEV): Potentiation of lethality in mice by microwave radiation"],"prefix":"10.1002","volume":"12","author":[{"given":"David G.","family":"Lange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sedmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_1","series-title":"Pan American Sanitary Bureau. 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