{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:25:14Z","timestamp":1784237114441,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the efficacy of pulsed electromagnetic field (PEMF) at different frequencies during knee osteoarthritis (OA) progression. Ten\u2010week\u2010old male wild\u2010type (WT) mice undergoing the destabilization of the medial meniscus (DMM) surgery were randomly divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910 each) respectively: DMM, DMM with three PEMF exposure (8, 50, or 75\u2009Hz). PEMF (3.8\u2009mT, 1\u2009h\/day) at different frequencies was applied for 4 weeks. Von Frey test, histological assessment, RT\u2010PCR, immunohistochemical staining, and microcomputed tomography (CT) were performed. PEMF at three frequencies (8, 50, and 75\u2009Hz) decreased the Osteoarthritis Research Society International (OARSI) scores to different extents compared to the DMM group. The mRNA and protein expressions of MMP13 and aggrecan (Acan) in cartilage were improved in three PEMF groups; PEMF at 50 and 75\u2009Hz had better positive effects than PEMF at 8\u2009Hz. The increased synovitis was attenuated by 75\u2009Hz PEMF. 75 and 50\u2009Hz PEMF groups had a beneficial effect on increasing 50% paw withdrawal threshold (PWT) compared with the DMM group. Micro\u2010CT analysis showed that 75\u2009Hz PEMF group, compared with DMM group, increased trabecular thickness (Tb.Th) of femur and bone volume\/total volume (BV\/TV) of femoral condyle and femur, and decreased bone surface\/bone volume (BS\/BV) of tibia. The study demonstrated that PEMF at 75\u2009Hz could attenuate symptomatic and structural knee OA progression. Bioelectromagnetics. 00:00\u201300, 2025. \u00a9 2025 Bioelectromagnetics Society.\n                  <\/jats:p>","DOI":"10.1002\/bem.70016","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:05:50Z","timestamp":1753783550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Whole\u2010Body Exposure to Pulsed Electromagnetic Field at Different Frequencies on Knee Osteoarthritis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7757-8486","authenticated-orcid":false,"given":"Xiaotian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev426"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40730"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2007.03.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.03.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.01.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12696"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.04.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15368378.2021.2021933"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15368378.2024.2314108"},{"key":"e_1_2_10_15_1","first-page":"347","article-title":"Emerging Medical Applications Based on Non\u2010Ionizing Electromagnetic Fields From 0 Hz to 10 THz","volume":"12","author":"Mattsson M. 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