{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:50:44Z","timestamp":1791172244612,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Various studies have indicated that moderate static magnetic fields (MMFs) could inhibit bone loss and facilitate bone fracture healing. The biological effects of static magnetic fields vary depending on their orientation. Herein, we investigated the effects of MMF in different orientations on bone loss in ovariectomized (OVX) mice. The OVX mice were exposed to 20\u2013100\u2009mT MMFs with magnetic field lines oriented in the N\u2010upward and S\u2010upward directions for 8 weeks, respectively. Then, the bone mass, microarchitecture, mechanical properties, and turnover markers were evaluated. The results showed that both N\u2010upward and S\u2010upward MMFs exposure prevented the decrease of bone mineral density (BMD) and bone mineral content (BMC) induced by OVX, improved the bone microstructure, and enhanced the bone mechanical properties. The serum bone formation markers propeptide of type I procollagen (P1NP) and osteocalcin (OCN) have been increased by MMFs exposure, while bone resorption marker beta\u2010isomer of the C\u2010terminal telopeptide of type I collagen (\u03b2\u2010CTX) has been decreased by MMFs exposure in OVX mice. Meanwhile, MMFs exposure decreased osteoclast distribution on the surface of trabecular bone and cortical bone. N\u2010upward MMF exposure increased osteoblast number per bone surface (N.Ob\/BS) in trabecular bone. Moreover, mice under N\u2010upward orientation MMFs exposure exhibited higher stiffness, elastic modulus, and total energy absorption in terms of tibial mechanical properties compared to S\u2010upward orientation MMFs exposure. In conclusion, these results demonstrate that 20\u2013100\u2009mT MMFs exposure with different orientations suppressed the ovariectomized\u2010induced bone loss and mechanical properties degradation in mice, and the N\u2010upward MMFs hold superior effects.<\/jats:p>","DOI":"10.1002\/bem.70037","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:09:20Z","timestamp":1766401760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Different Orientations Moderate Static Magnetic Fields Prevent Bone Loss and Improve the Mechanical Properties in Ovariectomized Mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Shenghang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, People's Hospital of Longhua Affiliated Hospital of Southern Medical University Shenzhen China"},{"name":"School of Chinese Medicine, Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ) Hong Kong Baptist University Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen China"},{"name":"Key Laboratory for Space Biosciences and Biotechnology Northwestern Polytechnical University Xi'an Shaanxi China"},{"name":"School of Life Sciences Northwestern Polytechnical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Wang","sequence":"additional","affiliation":[{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen China"},{"name":"Key Laboratory for Space Biosciences and Biotechnology Northwestern Polytechnical University Xi'an Shaanxi China"},{"name":"School of Life Sciences Northwestern Polytechnical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cai","sequence":"additional","affiliation":[{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen China"},{"name":"Key Laboratory for Space Biosciences and Biotechnology Northwestern Polytechnical University Xi'an Shaanxi China"},{"name":"School of Life Sciences Northwestern Polytechnical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Ren","sequence":"additional","affiliation":[{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen China"},{"name":"Key Laboratory for Space Biosciences and Biotechnology Northwestern Polytechnical University Xi'an Shaanxi China"},{"name":"School of Life Sciences Northwestern Polytechnical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen China"},{"name":"Key Laboratory for Space Biosciences and Biotechnology Northwestern Polytechnical University Xi'an Shaanxi China"},{"name":"School of Life Sciences Northwestern Polytechnical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, People's Hospital of Longhua Affiliated Hospital of Southern Medical University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, People's Hospital of Longhua Affiliated Hospital of Southern Medical University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, People's Hospital of Longhua Affiliated Hospital of Southern Medical University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengfeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, People's Hospital of Longhua Affiliated Hospital of Southern Medical University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5418-6240","authenticated-orcid":false,"given":"Peng","family":"Shang","sequence":"additional","affiliation":[{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen China"},{"name":"Key Laboratory for Space Biosciences and Biotechnology Northwestern Polytechnical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, People's Hospital of Longhua Affiliated Hospital of Southern Medical University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-070313-022841"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214298"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147403"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"e_1_2_7_7_1","first-page":"45","article-title":"[Consolidation of Bone Fragments in a Constant Magnetic Field]","volume":"32","author":"Degen I. L.","year":"1971","journal-title":"Ortopediia Travmatologiia i Protezirovanie"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509250112"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.05.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB02299D"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.02.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01498.2003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.21903"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.22126"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.10.1814"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2016.1135266"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-5109-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010051"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-062117-121139"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4029176"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.08.029"},{"key":"e_1_2_7_22_1","article-title":"Magnetic Fields Affect Alcoholic Liver Disease by Liver Cell Oxidative Stress and Proliferation Regulation","volume":"6","author":"Song C.","year":"2023","journal-title":"Research A Journal of Science and Its Applications"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108168"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111085"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/15368378.2018.1458627"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2307353"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-023-01170-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-005-0627-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00172-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0191803"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMAG.2021.3072148"},{"key":"e_1_2_7_32_1","article-title":"A Static Magnetic Field Improves Iron Metabolism and Prevents High\u2010Fat\u2010Diet\/Streptozocin\u2010Induced Diabetes","volume":"2","author":"Yu B.","year":"2021","journal-title":"Innovation"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2022.09.002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.10.024"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/15368378.2018.1458626"}],"container-title":["Bioelectromagnetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bem.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T12:04:51Z","timestamp":1766750691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bem.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/bem.70037"],"URL":"https:\/\/doi.org\/10.1002\/bem.70037","archive":["Portico"],"relation":{},"ISSN":["0197-8462","1521-186X"],"issn-type":[{"value":"0197-8462","type":"print"},{"value":"1521-186X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70037"}}